ReviewEnvironmental health perspectives1992
Perinatal and multigenerational effect of carcinogens: possible contribution to determination of cancer susceptibility.
Review in Environmental health perspectives, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
- DNA methylation changes involved in the tumor increase in F2 males born to gestationally arsenite-exposed F1 male mice.Cancer science · 2019Article
- Environmental Carcinogenesis and Transgenerational Transmission of Carcinogenic Risk: From Genetics to Epigenetics.International journal of environmental research and public health · 2018Article
- Current Knowledge on Endocrine Disrupting Chemicals (EDCs) from Animal Biology to Humans, from Pregnancy to Adulthood: Highlights from a National Italian Meeting.International journal of molecular sciences · 2018Review
- Environmentally induced epigenetic transgenerational inheritance of phenotype and disease.Molecular and cellular endocrinology · 2012Review
- Epidemiology of childhood cancer.Environmental health : a global access science source · 2011Article
- Developmental and environmental origins of breast cancer: DDT as a case study.Reproductive toxicology (Elmsford, N.Y.) · 2011Article
- Epigenetic transgenerational actions of vinclozolin on promoter regions of the sperm epigenome.PloS one · 2010Article
- Prenatal exposure to bisphenol a at environmentally relevant doses adversely affects the murine female reproductive tract later in life.Environmental health perspectives · 2009Article
- The limits of two-year bioassay exposure regimens for identifying chemical carcinogens.Environmental health perspectives · 2008Article
- In Memoriam: Lorenzo Tomatis 1929-2007.Environmental health perspectives · 2008Article
- What is an epigenetic transgenerational phenotype? F3 or F2.Reproductive toxicology (Elmsford, N.Y.) · 2008Review
- Possible mechanisms of action of environmental contaminants on St. Lawrence beluga whales (Delphinapterus leucas).Environmental health perspectives · 1995Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perinatal exposure to carcinogens may contribute to the determination of susceptibility to cancer in two situations: a) exposure in utero of embryonal or fetal somatic cells to carcinogens, and b) prezygotic exposure of the germ cells of one or both parents to carcinogens. Epidemiological as well as experimental studies demonstrate that exposure to carcinogens in utero increases the occurrence of cancer postnatally. Studies with experimental animals suggest that prezygotic exposure of germ cells to carcinogens can result in an increased incidence of cancer not only in immediate but also in subsequent generations. Although several studies suggest a transgeneration effect of carcinogens in human populations, the evidence cannot yet be considered conclusive. In particular, while some hypotheses can be advanced, the mechanism(s) by which increased susceptibility or predisposition to cancer may be transmitted via the germ cells has not yet been clarified. In conjunction with exposure both in utero and prezygotically, it is important to consider postnatal exposure to possible tumor-promoting agents. Results from experimental animals suggest that oncogenes can be activated transplacentally, and human studies indicate that tumor-suppressor gene inactivation may be involved in the transgenerational effect of carcinogens.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.