ReviewBulletin of the World Health Organization1992
The magnitude of the global problem of diarrhoeal disease: a ten-year update.
Review in Bulletin of the World Health Organization, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
156 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- A systematic review and meta-analysis: the therapeutic and preventive effect of Lactobacillus reuteri DSM 17,938 addition in children with diarrhea.BMC gastroenterology · 2023Pooled it
- Diarrhea incidence in low- and middle-income countries in 1990 and 2010: a systematic review.BMC public health · 2012Pooled it
- Oral immunoglobulin for the treatment of rotavirus diarrhea in low birth weight infants.The Cochrane database of systematic reviews · 2011Pooled it
- Oral versus intravenous rehydration for treating dehydration due to gastroenteritis in children.The Cochrane database of systematic reviews · 2006Pooled it
- Trial
- Risk factors associated with recurrent diarrheal illnesses among children in Kabul, Afghanistan: a prospective cohort study.PloS one · 2015Trial
- Resolution of acute gastroenteritis symptoms in children and adults treated with a novel polyphenol-based prebiotic.World journal of gastroenterology · 2014Trial
- Micronutrients (including zinc) reduce diarrhoea in children: the Pakistan Sprinkles Diarrhoea Study.Archives of disease in childhood · 2006Trial
- Lactobacillus casei strain GG in the treatment of infants with acute watery diarrhea: a randomized, double-blind, placebo controlled clinical trial [ISRCTN67363048].BMC pediatrics · 2004Trial
- Storage conditions and antiviral efficacy of yeast-derived vacuoles on T4 virus.Microbiology spectrum · 2026Article
- The Effect of Oral Nutritional Supplements in Improving the Condition of Children with Diarrhea: A Systematic Review.Pediatric gastroenterology, hepatology & nutrition · 2025Review
- Space-Time Clustering and Socioeconomic Factors Associated with Mortality from Diarrhea in Alagoas, Northeastern Brazil: A 20-Year Population-Based Study.Tropical medicine and infectious disease · 2022Article
- Article
- Bioengineering of LAB vector expressing Haemolysin co-regulated protein (Hcp): a strategic approach to control gut colonization of Campylobacter jejuni in a murine model.Gut pathogens · 2021Article
- Biological and computational studies provide insights intoBiochemistry and biophysics reports · 2021Article
- Low Osmolarity Oral Rehydration Salt Solution (LORS) in Management of Dehydration in Children.Indian pediatrics · 2021Article
- Tannins extract from Galla Chinensis can protect mice from infection by Enterotoxigenic Escherichia coli O101.BMC complementary medicine and therapies · 2021Article
- The performance of licensed rotavirus vaccines and the development of a new generation of rotavirus vaccines: a review.Human vaccines & immunotherapeutics · 2021Review
- Article
- Characterization and antibiotic resistance pattern of diffusely adherentNew microbes and new infections · 2020Article
96 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to update global estimates of diarrhoeal morbidity and mortality in developing countries, we carried out a review of articles published from 1980 to the present and calculated median estimates for the incidence of diarrhoea and diarrhoeal mortality among under-5-year-olds. The incidence of diarrhoea obtained (2.6 episodes per child per year) was virtually the same as that estimated by Snyder & Merson in 1982, while the global mortality estimate was lower (3.3 million deaths per year; range, 1.5-5.1 million). The mortality estimate is based on a small number of active surveillance and prospective studies, and thus associated with a large degree of uncertainty, reflecting the weakness of the global database. However, many surveys reporting reductions in mortality in several locations are consistent with a decreased estimate for mortality. More accurate execution of WHO survey methods, including population-based sampling in representative locations, and repeat surveys every 5 years, are needed to monitor the progress of diarrhoeal disease control programmes and trends in diarrhoeal morbidity and mortality over time.
Indexed as
Identifiers
1486666PMC2393403What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.