ArticleNaunyn-Schmiedeberg's archives of pharmacology1992
K+ channel openers, cromakalim and Ki4032, inhibit agonist-induced Ca2+ release in canine coronary artery.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 56 citations in OpenAlex.
- Engaging biological oscillators through second messenger pathways permits emergence of a robust gastric slow-wave during peristalsis.PLoS computational biology · 2021Article
- Introduction to ion channels and calcium signaling in the microcirculation.Current topics in membranes · 2020Review
- KMicrocirculation (New York, N.Y. : 1994) · 2018Review
- Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.Comprehensive Physiology · 2017Review
- Potassium Channels in Regulation of Vascular Smooth Muscle Contraction and Growth.Advances in pharmacology (San Diego, Calif.) · 2017Review
- A theoretical model of slow wave regulation using voltage-dependent synthesis of inositol 1,4,5-trisphosphate.Biophysical journal · 2002Article
- Hypoxia does not activate ATP-sensitive K+ channels in arteriolar muscle cells.Microcirculation (New York, N.Y. : 1994) · 2000Article
- Ion channels and vascular tone.Hypertension (Dallas, Tex. : 1979) · 2000Review
- Pharmacological evidence for a KATP channel in renin-secreting cells from rat kidney.The Journal of physiology · 1999Article
- Apamin- and nitric oxide-sensitive biphasic non-adrenergic non-cholinergic inhibitory junction potentials in the rat anococcygeus muscle.The Journal of physiology · 1998Article
- Effects of the potassium channel openers KRN4884 and levcromakalim on the contraction of rat aorta induced by A23187, compared with nifedipine.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- Evidence for mediation by endothelium-derived hyperpolarizing factor of relaxation to bradykinin in the bovine isolated coronary artery independently of voltage-operated Ca2+ channels.British journal of pharmacology · 1996Article
- Ba2+ differentially inhibits the Rb+ efflux promoting and the vasorelaxant effects of levcromakalim and minoxidil sulfate in rat isolated aorta.Naunyn-Schmiedeberg's archives of pharmacology · 1995Article
- Membrane potential modulates inositol 1,4,5-trisphosphate-mediated Ca2+ transients in guinea-pig coronary myocytes.The Journal of physiology · 1993Article
- Hyperpolarization induced by K+ channel openers inhibits Ca2+ influx and Ca2+ release in coronary artery.Cardiovascular drugs and therapy · 1993Article
- BRL 38227 (levcromakalim)-induced hyperpolarization reduces the sensitivity to Ca2+ of contractile elements in canine coronary artery.Naunyn-Schmiedeberg's archives of pharmacology · 1993Article
- Potassium channels in the peripheral microcirculation.Microcirculation (New York, N.Y. : 1994)Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of K+ channel openers, cromakalim and an acetoxyl derivative of KRN2391 (Ki4032), were studied on force of contraction, increases in intracellular calcium concentration ([Ca2+]i) measured by fura-2 and inositol 1,4,5-trisphosphate (IP3) production induced by the thromboxane A2 analogue, U46619, in canine coronary arteries. Upon single dose applications of U46619 at 300 nmol/l, phasic and tonic increases in [Ca2+]i and force were seen, which were almost abolished by cromakalim (10 mumol/l) and Ki4032 (100 mumol/l). In the absence of extracellular Ca2+, U46619 induced a transient increase in [Ca2+]i with a contraction. Cromakalim (0.01-10 mumol/l) and Ki4032 (0.1-100 mumol/l) concentration-dependently inhibited the increases in [Ca2+]i and contraction. The inhibitory effects of cromakalim and Ki4032 were blocked by the K+ channel blocker tetrabutylammonium (TBA) and counteracted by 20 mmol/l KCl-induced depolarization. Cromakalim and Ki4032 did not affect caffeine-induced Ca2+ release. Cromakalim reduced U46619-induced IP3 production significantly and TBA blocked this inhibitory effect. These results suggest that the hyperpolarization of the plasma membrane by K+ channel openers inhibits the production of IP3 and Ca2+ release from intracellular stores related to stimulation of the thromboxane A2 receptor.
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