ArticleJapanese journal of cancer research : Gann1992
Inactivation of the p53 gene is not required for tumorigenesis of medullary thyroid carcinoma or pheochromocytoma.
Article in Japanese journal of cancer research : Gann, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Protective Effects of Lactobacillus curvatus Against Acute Lead and Cadmium Toxicity in Caspian Kutum (Rutilus frisii, Nordmann, 1840): Growth Performance, Chemical Composition, Hematological Characteristics, Serum Biochemical Parameters, and Immune Response.Biological trace element research · 2026Article
- Minor role of TP53 and TERT promoter mutations in medullary thyroid carcinoma: report of new cases and revision of the literature.Endocrine · 2025Review
- Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS.The Journal of clinical endocrinology and metabolism · 2013Article
- The Ki67 index a prognostic marker in medullary thyroid carcinoma.British journal of cancer · 2003Article
- Molecular genetic alterations in adrenal and extra-adrenal pheochromocytomas and paragangliomas.Endocrine pathology · 2003Review
- The clinicopathological features and importance of p53, Rb, and mdm2 expression in phaeochromocytomas and paragangliomas.Journal of clinical pathology · 2001Article
- Bcl-2 and c-Myc, but not bax and p53, are expressed during human medullary thyroid tumorigenesis.The American journal of pathology · 1998Article
- Concurrent Pheochromocytoma, Paraganglioma, Papillary Thyroid Carcinoma, and Desmoid Tumor: A Case Report with Analyses at the Molecular Level.Endocrine pathology · 1998Article
- p53 abnormalities are rare events in neuroendocrine (Merkel cell) carcinoma of the skin. An immunohistochemical and SSCP analysis.Virchows Archiv : an international journal of pathology · 1997Article
- Possible Relation of p53 and mdm-2 Oncoprotein Expression in Thyroid Carcinoma: A Molecular-Pathological and Immunohistochemical Study on Paraffin-Embedded Tissue.Endocrine pathology · 1996Article
- Molecular and immunohistochemical analysis of P53 in phaeochromocytoma.British journal of cancer · 1995Article
- Point mutations of ras and Gs alpha subunit genes in thyroid tumors.Japanese journal of cancer research : Gann · 1995Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A polymerase chain reaction (PCR)-mediated RNase protection analysis was performed to detect subtle genetic alterations of p53 in medullary thyroid carcinoma (MTC) and pheochromocytoma. None of the 30 pheochromocytomas showed abnormal RNase protection patterns. Only one of 32 MTCs showed an abnormal pattern, and subsequent DNA sequencing of the PCR product revealed that it had a G to C transversion in codon 49 that resulted in a change from aspartic acid to histidine. However, this was a sporadic MTC with no specific clinicopathological characteristics. On the basis of a previous report that genes on chromosome 17p were not deleted in MTCs and were relatively infrequently deleted in pheochromocytomas, our results suggest that the p53 gene is not involved in tumorigenesis of MTC or pheochromocytoma.
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