ArticleHuman genetics1992
Complete characterization of a large marker chromosome by reverse and forward chromosome painting.
Article in Human genetics, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 55 citations in OpenAlex.
- Centromeric instability and chromoanasynthesis observed in nine supernumerary marker chromosomes resolved with long-read genome sequencing.Genome research · 2026Article
- The First Neocentric, Discontinuous, and Complex Small Supernumerary Marker Chromosome Composed of 7 Euchromatic Blocks Derived from 5 Different Chromosomes.Biomedicines · 2022Article
- Reverse painting highlights the origin of chromosome aberrations.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2004Review
- A supernumerary marker chromosome originating from two different regions of chromosome 18.Journal of medical genetics · 2000Article
- Mosaic supernumerary ring chromosome 19 identified by comparative genomic hybridisation.Journal of medical genetics · 1998Article
- Generation of chromosome fragment specific bovine DNA sequences by microdissection and DOP-PCR.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- Complete and precise characterization of marker chromosomes by application of microdissection in prenatal diagnosis.Human genetics · 1995Article
- Partial disomy of Xp and the presence of SRY in a phenotypic female.Journal of medical genetics · 1995Article
- Comparative genomic hybridization in clinical cytogenetics.American journal of human genetics · 1995Article
- Localization of the human soluble epoxide hydrolase gene (EPHX2) to chromosomal region 8p21-p12.Human genetics · 1995Article
- A stable acentric marker chromosome: possible existence of an intercalary ancient centromere at distal 8p.American journal of human genetics · 1994Article
- Delineation of marker chromosomes by reverse chromosome painting using only a small number of DOP-PCR amplified microdissected chromosomes.Human genetics · 1994Article
- Tetrasomy 15q: two marker chromosomes with no detectable alpha-satellite DNA.American journal of human genetics · 1994Article
- Predisposition for breast cancer in carriers of constitutional translocation 11q;22q.American journal of human genetics · 1994Article
- Characterization of supernumerary ring marker chromosomes by fluorescence in situ hybridization (FISH).American journal of human genetics · 1993Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marker chromosome are small supernumerary chromosomes that are sometimes associated with developmental abnormalities. Hence, the genes involved in such cases provide an interesting approach to understanding developmental abnormalities in man. As a first step towards isolating such sequences, marker chromosomes need complete characterization. By combining chromosome isolation by flow sorting and the "degenerate oligonucleotide primed - polymerase chain reaction", we have constructed a DNA library specific for a marker chromosome found in a child with severe developmental abnormalities. We used fluorescent in situ hybridization of the library onto normal metaphase spreads ("reverse chromosome painting") and were thus able to determine that the marker consists of the centromeric part of chromosome 7, the telomeric region of the long arm of chromosome 5 and the telomeric region of the short arm of the X-chromosome. Subsequently, we hybridized normal chromosome-specific libraries of the relevant chromosomes onto metaphases containing the marker chromosome ("forward chromosome painting") and could in this manner establish the precise location of the different chromosome regions on the marker chromosome itself. This is a general approach suitable for outlining marker chromosomes in detail, and will aid the identification of the genes involved.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.