ArticleImmunology1992
CD3-gamma, -delta, -epsilon, -zeta, T-cell receptor-alpha and -beta transcripts are independently regulated during thymocyte ontogeny and T-cell activation.
Article in Immunology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 11 citations in OpenAlex.
- Preparing unbiased T-cell receptor and antibody cDNA libraries for the deep next generation sequencing profiling.Frontiers in immunology · 2013Article
- Distal V beta promoters transcribe novel T-cell receptor-beta transcripts in early development.Immunology · 1998Article
- Patho- and immunobiology of malignant mesothelioma: characterisation of tumour infiltrating leucocytes and cytokine production in a murine model.Cancer immunology, immunotherapy : CII · 1994Article
- T cell receptor-beta mRNA splicing: regulation of unusual splicing intermediates.Molecular and cellular biology · 1993Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
CD3 proteins transduce signals delivered from the T-cell receptor (TcR) for antigen. The genes that encode the individual CD3 subunits are asynchronously regulated in tumour cell lines in vitro. In this report, we examined the expression of individual CD3 and TcR genes during normal murine thymocyte ontogeny in vivo. We show that CD3-gamma, -delta, -epsilon, and zeta transcripts are all expressed on Day 14 post-coitum (p.c.), along with IL-2R alpha and Thy-1 mRNA, and prior to the expression of functional TcR-alpha, -beta, CD4 and CD8 transcripts. Individual CD3 subunits display unique patterns of increased gene expression as ontogeny proceeds. Unique regulation of these T-cell transcripts is also observed in splenic cells activated with the T-cell mitogen concanavalin A (Con A). CD3-delta, -zeta, TcR-alpha and -beta mRNA expression increases, whilst CD3-gamma and -epsilon mRNA levels decrease after mitogenic activation. The potential implications of this regulation on the composition and expression of the TcR/CD3 complex during T-cell ontogeny and activation is discussed.
Indexed as
Identifiers
1478692PMC1421723W72712021What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.