ArticleDiabetologia1992
Increased vascular permeability in pancreas of diabetic rats: detection with high resolution protein A-gold cytochemistry.
Article in Diabetologia, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Highly blood perfused, highly metabolically active pancreatic islets may be more susceptible for immune attack.Physiological reports · 2020Article
- Zn2+ chelation by serum albumin improves hexameric Zn2+-insulin dissociation into monomers after exocytosis.PloS one · 2017Article
- Large Gliadin Peptides Detected in the Pancreas of NOD and Healthy Mice following Oral Administration.Journal of diabetes research · 2016Article
- Diagnostic and prognostic utility of non-invasive imaging in diabetes management.World journal of diabetes · 2015Review
- Magnetic resonance imaging of the pancreas in streptozotocin-induced diabetic rats: Gadofluorine P and Gd-DOTA.World journal of gastroenterology · 2015Article
- Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Empirical mathematical model for dynamic manganese-enhanced MRI of the murine pancreas for assessment of β-cell function.Magnetic resonance imaging · 2013Article
- Imaging the pancreatic vasculature in diabetes models.Diabetes/metabolism research and reviews · 2011Article
- Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients.The Journal of clinical investigation · 2011Article
- Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes.The Journal of clinical investigation · 2005Article
- Endothelial vesicles in the blood-brain barrier: are they related to permeability?Cellular and molecular neurobiology · 2000Review
- Early insulitis and the islet vascular system.Diabetologia · 1993Article
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5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of the pancreatic microcirculation in the pathogenesis of Type 1 (insulin-dependent) diabetes mellitus remains poorly understood. Herein, a method is described for the ultrastructural investigation of the integrity of the pancreatic microvasculature. The method consists of histochemical detection and isolation of the islets followed by albumin and protein A-gold immunocytochemistry, whereby the distribution of endogenous albumin is used as a marker of endothelial integrity. This technique, applied to the study of spontaneously diabetic rats, reveals a selective increase in permeability of islet capillaries and post-capillary venules at the onset of diabetes, while acinar capillaries and arterioles remain intact. At 50 days of age, before the onset of diabetes, the microvasculature of diabetes-prone rats shows no alterations in permeability to albumin. When used in conjunction with morphometric analyses, this methodological approach may be useful for further studies in pathologic or experimental conditions involving the pancreatic microvasculature.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.