ArticleProceedings of the National Academy of Sciences of the United States of America2004
Ceramidase expression facilitates membrane turnover and endocytosis of rhodopsin in photoreceptors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking.Cell reports · 2016Article
- The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration.PLoS biology · 2014Article
- Identification and biochemical characterization of Laodelphax striatellus neutral ceramidase.Insect molecular biology · 2013Article
- Drosophila fatty acid transport protein regulates rhodopsin-1 metabolism and is required for photoreceptor neuron survival.PLoS genetics · 2012Article
- Ceramide signaling in retinal degeneration.Advances in experimental medicine and biology · 2012Review
- Molecular cloning and characterization of neutral ceramidase homologue from the red flour beetle, Tribolium castaneum.Biochimie · 2011Article
- Sphingosine kinases and their metabolites modulate endolysosomal trafficking in photoreceptors.The Journal of cell biology · 2011Article
- CDase is a pan-ceramidase in Drosophila.Molecular biology of the cell · 2011Article
- Regulating survival and development in the retina: key roles for simple sphingolipids.Journal of lipid research · 2010Review
- Requirement for an enzymatic visual cycle in Drosophila.Current biology : CB · 2010Article
- Ceramide kinase regulates phospholipase C and phosphatidylinositol 4, 5, bisphosphate in phototransduction.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Mechanistic insights into the hydrolysis and synthesis of ceramide by neutral ceramidase.The Journal of biological chemistry · 2009Article
- Sphingolipids and membrane biology as determined from genetic models.Prostaglandins & other lipid mediators · 2008Review
- Article
- Phototransduction and retinal degeneration in Drosophila.Pflugers Archiv : European journal of physiology · 2007Review
- Drosophila melanogaster Scramblases modulate synaptic transmission.The Journal of cell biology · 2006Article
- Ceramidase regulates synaptic vesicle exocytosis and trafficking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Transgenic expression of ceramidase suppresses retinal degeneration in Drosophila arrestin and phospholipase C mutants. Here, we show that expression of ceramidase facilitates the dissolution of incompletely formed and inappropriately located elements of rhabdomeric membranes in ninaE(I17) mutants lacking the G protein receptor Rh1 in R1-R6 photoreceptor cells. Ceramidase expression facilitates the endocytic turnover of Rh1. Although ceramidase expression aids the removal of internalized rhodopsin, it does not affect the turnover of Rh1 in photoreceptors maintained in dark, where Rh1 is not activated and thus has a slower turnover and a long half-life. Therefore, the phenotypic consequence of ceramidase expression in photoreceptors is caused by facilitation of endocytosis. This study provides mechanistic insight into the sphingolipid biosynthetic pathway-mediated modulation of endocytosis and suppression of retinal degeneration.
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