ArticleThe Journal of experimental medicine2004
Developmental separation of V(D)J recombinase expression and initiation of IgH recombination in B lineage progenitors in vivo.
Article in The Journal of experimental medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Novel molecular mechanism for generating NK-cell fitness and memory.European journal of immunology · 2015Review
- Clinical observations on chemotherapy curable malignancies: unique genetic events, frozen development and enduring apoptotic potential.BMC cancer · 2015Article
- Article
- Apurinic/apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- The ontogeny and fate of NK cells marked by permanent DNA rearrangements.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Article
- Lineage specification and plasticity in CD19- early B cell precursors.The Journal of experimental medicine · 2006Article
- From B cell to plasma cell: regulation of V(D)J recombination and antibody secretion.Immunologic research · 2006Review
- E47 is required for V(D)J recombinase activity in common lymphoid progenitors.The Journal of experimental medicine · 2005Article
- Bone marrow microenvironmental changes underlie reduced RAG-mediated recombination and B cell generation in aged mice.The Journal of experimental medicine · 2004Article
- B lineage-specific regulation of V(D)J recombinase activity is established in common lymphoid progenitors.The Journal of experimental medicine · 2004Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In B lineage progenitors, V(D)J recombination occurs only during distinct stages of development and is restricted to immunoglobulin loci. This process is thought to be controlled by both regulated expression of the V(D)J recombinase and by limited accessibility of target loci to the recombinase complex. However, it is unknown whether these two processes occur concomitantly in developing B lineage progenitors or whether these events are temporally distinct and, therefore, potentially independently regulated. To distinguish between these possibilities, we developed a transgenic V(D)J recombination substrate that is not governed by the same chromatin remodeling constraints as endogenous immunoglobulin heavy chain (IgH) loci and examined the requirements for V(D)J recombination to initiate in early B lineage progenitors. We find that single B lineage precursors express an active V(D)J recombinase in vivo before the stage when IgH rearrangements are frequently detectable. Our results indicate that the onset of recombinase activity and the initiation of IgH recombination are developmentally distinct events in the B lineage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.