ArticleThe Journal of general physiology2004
Specificity of charge-carrying residues in the voltage sensor of potassium channels.
Article in The Journal of general physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Voltage-sensing domains: structural and functional diversity.European biophysics journal : EBJ · 2026Review
- Voltage-sensor gating charge interactions bimodally regulate voltage dependence and kinetics of calcium channel activation.The Journal of general physiology · 2025Article
- Effect of a sensing charge mutation on the deactivation of KV7.2 channels.The Journal of general physiology · 2024Article
- Exploring Flexibility and Folding Patterns Throughout Time in Voltage Sensors.Journal of molecular evolution · 2023Article
- Sweetening K-channels: what sugar taught us about permeation and gating.Frontiers in molecular biosciences · 2023Review
- Article
- Comparison of KHandbook of experimental pharmacology · 2021Article
- Gating-induced large aqueous volumetric remodeling and aspartate tolerance in the voltage sensor domain of Shaker KProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Pore size matters for potassium channel conductance.The Journal of general physiology · 2016Review
- Functional diversity of potassium channel voltage-sensing domains.Channels (Austin, Tex.) · 2016Review
- A self-consistent approach for determining pairwise interactions that underlie channel activation.The Journal of general physiology · 2014Article
- Interfacial gating triad is crucial for electromechanical transduction in voltage-activated potassium channels.The Journal of general physiology · 2014Article
- Mechanisms of activation of voltage-gated potassium channels.Acta naturae · 2014Article
- The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands.Cell research · 2013Article
- Exploring structure-function relationships between TRP and Kv channels.Scientific reports · 2013Article
- Leaky channels make weak muscles.The Journal of clinical investigation · 2012Article
- Microscopic origin of gating current fluctuations in a potassium channel voltage sensor.Biophysical journal · 2012Article
- Article
- Contributions of counter-charge in a potassium channel voltage-sensor domain.Nature chemical biology · 2011Article
- Lipid-dependent gating of a voltage-gated potassium channel.Nature communications · 2011Article
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Authors and funding
2 authors.
Funding
Abstract
Positively charged voltage sensors of sodium and potassium channels are driven outward through the membrane's electric field upon depolarization. This movement is coupled to channel opening. A recent model based on studies of the KvAP channel proposes that the positively charged voltage sensor, christened the "voltage-sensor paddle", is a peripheral domain that shuttles its charged cargo through membrane lipid like a hydrophobic cation. We tested this idea by attaching charged adducts to cysteines introduced into the putative voltage-sensor paddle of Shaker potassium channels and measuring fractional changes in the total gating charge from gating currents. The only residues capable of translocating attached charges through the membrane-electric field are those that serve this function in the native channel. This remarkable specificity indicates that charge movement involves highly specialized interactions between the voltage sensor and other regions of the protein, a mechanism inconsistent with the paddle model.
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