ArticleNeuro-oncology2004
Review of microdialysis in brain tumors, from concept to application: first annual Carolyn Frye-Halloran symposium.
Article in Neuro-oncology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 52 citations in OpenAlex.
- The neuropharmacokinetics of temozolomide in patients with resectable brain tumors: potential implications for the current approach to chemoradiation.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Trial
- Window of opportunity evaluation of blood-brain barrier permeability heterogeneity within and across high-grade glioma patients.Neuro-oncology · 2026Article
- Co-evolution of glioma and immune microenvironment.Journal for immunotherapy of cancer · 2024Review
- Quantitative monitoring and modelling of retrodialysis drug delivery in a brain phantom.Scientific reports · 2023Article
- Microdialysis as a tool for antibiotic assessment in patients with diabetic foot: a review.Frontiers in endocrinology · 2023Review
- Foe or friend? Janus-faces of the neurovascular unit in the formation of brain metastases.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Review
- In vivo neurochemical measurements in cerebral tissues using a droplet-based monitoring system.Nature communications · 2017Article
- Ganciclovir concentrations in the cerebral extracellular space after valganciclovir treatment; a case study.BMJ case reports · 2015Article
- Observational Evaluations of Mice during Cerebral Microdialysis for Pediatric Brain Tumor Research.Journal of the American Association for Laboratory Animal Science : JAALAS · 2015Article
- Tumor Interstitial Fluid Formation, Characterization, and Clinical Implications.Frontiers in oncology · 2015Review
- Microdialysis Monitoring of CSF Parameters in Severe Traumatic Brain Injury Patients: A Novel Approach.Frontiers in neurology · 2014Article
- Clinical microdialysis in neuro-oncology: principles and applications.Chinese journal of cancer · 2011Review
- Microdialysis for assessing intratumoral drug disposition in brain cancers: a tool for rational drug development.Expert opinion on drug metabolism & toxicology · 2010Review
- Influence of blood-brain barrier efflux pumps on the distribution of vincristine in brain and brain tumors.Neuro-oncology · 2010Article
- Interstitial fluid: the overlooked component of the tumor microenvironment?Fibrogenesis & tissue repair · 2010Article
- Droplet-based microdialysis-Concept, theory, and design considerations.Journal of chromatography. A · 2008Article
Corrections and comments
- Erratum issued
Authors and funding
14 authors at 11 institutions in 1 country.
Funding
Abstract
In individuals with brain tumors, pharmacodynamic and pharmacokinetic studies of therapeutic agents have historically used analyses of drug concentrations in serum or cerebrospinal fluid, which unfortunately do not necessarily reflect concentrations within the tumor and adjacent brain. This review article introduces to neurological and medical oncologists, as well as pharmacologists, the application of microdialysis in monitoring drug metabolism and delivery within the fluid of the interstitial space of brain tumor and its surroundings. Microdialysis samples soluble molecules from the extracellular fluid via a semipermeable membrane at the tip of a probe. In the past decade, it has been used predominantly in neurointensive care in the setting of brain trauma, vasospasm, epilepsy,and intracerebral hemorrhage. At the first Carolyn Frye-Halloran Symposium held at Massachusetts General Hospital in March 2002, the concept of microdialysis was extended to specifically address its possible use in treating brain tumor patients. In doing so we provide a rationale for the use of this technology by a National Cancer Institute consortium, New Approaches to Brain Tumor Therapy, to measure levels of drugs in brain tissue as part of phase 1 trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.