ArticleMolecular biology of the cell2004
Impaired p53 expression, function, and nuclear localization in calreticulin-deficient cells.
Article in Molecular biology of the cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 74 citations in OpenAlex.
- Radiosensitization of calreticulin-overexpressing human glioma cell line by the polyphenolic acetate 7, 8-diacetoxy-4-methylcoumarin.Cancer reports (Hoboken, N.J.) · 2022Article
- Restoring the Immunity in the Tumor Microenvironment: Insights into Immunogenic Cell Death in Onco-Therapies.Cancers · 2021Review
- An IMiD-induced SALL4 degron system for selective degradation of target proteins.Communications biology · 2020Article
- Current Approaches for Combination Therapy of Cancer: The Role of Immunogenic Cell Death.Cancers · 2020Review
- Low-Dose Gemcitabine Treatment Enhances Immunogenicity and Natural Killer Cell-Driven Tumor Immunity in Lung Cancer.Frontiers in immunology · 2020Article
- Measuring cell cycle-dependent DNA damage responses and p53 regulation on a cell-by-cell basis from image analysis.Cell cycle (Georgetown, Tex.) · 2018Article
- Profiling of Signaling Proteins in Penumbra After Focal Photothrombotic Infarct in the Rat Brain Cortex.Molecular neurobiology · 2017Article
- Activation of theDisease models & mechanisms · 2017Article
- Activation of the EIF2α/ATF4 and ATF6 Pathways in DU-145 Cells by Boric Acid at the Concentration Reported in Men at the US Mean Boron Intake.Biological trace element research · 2017Article
- SIRT1 Limits Adipocyte Hyperplasia through c-Myc Inhibition.The Journal of biological chemistry · 2016Article
- Calreticulin mediates an invasive breast cancer phenotype through the transcriptional dysregulation of p53 and MAPK pathways.Cancer cell international · 2016Article
- Transcriptome profiling identifies p53 as a key player during calreticulin deficiency: Implications in lipid accumulation.Cell cycle (Georgetown, Tex.) · 2015Article
- Immunogenic cell death: can it be exploited in PhotoDynamic Therapy for cancer?BioMed research international · 2013Review
- Programmed cell removal: a new obstacle in the road to developing cancer.Nature reviews. Cancer · 2011Review
- Changes in tumor growth and metastatic capacities of J82 human bladder cancer cells suppressed by down-regulation of calreticulin expression.The American journal of pathology · 2011Article
- Characterization of a diverse secretome generated by the mouse preimplantation embryo in vitro.Reproductive biology and endocrinology : RB&E · 2010Article
- Expression of calreticulin is associated with infiltration of T-cells in stage IIIB colon cancer.World journal of gastroenterology · 2010Article
- Calreticulin: non-endoplasmic reticulum functions in physiology and disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Review
- Article
- Development of a malignancy-associated proteomic signature for diffuse large B-cell lymphoma.The American journal of pathology · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tumor suppressor protein, p53 is a transcription factor that not only activates expression of genes containing the p53 binding site but also can repress the expression of some genes lacking this binding site. Previous studies have shown that overexpression of wild-type p53 leads to apoptosis and cell cycle arrest. DNA damage, such as that caused by UV irradiation, results in p53 stabilization and nuclear localization that subsequently induces apoptosis. Recently, the level of calreticulin (CRT) has been correlated with the rate of apoptosis. Therefore, the aim of this study was to investigate the role of CRT in the regulation of apoptosis via modulating p53 function and expression. Here we show a significant decrease in both basal and DNA damage induced p53 functions in the CRT-deficient cells (crt-/-). This study is the first to demonstrate that CRT function is required for the stability and localization of the p53 protein. By using immuonocytochemical techniques, we showed that observed changes in p53 in the crt-/- cells are due to the nuclear accumulation of Mdm2 (murine double minute gene). These results, lead us to conclude that CRT regulates p53 function by affecting its rate of degradation and nuclear localization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.