ArticleMolecular biology of the cell2004
The Oxa2 protein of Neurospora crassa plays a critical role in the biogenesis of cytochrome oxidase and defines a ubiquitous subbranch of the Oxa1/YidC/Alb3 protein family.
Article in Molecular biology of the cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 78 citations in OpenAlex.
- Biallelic variants in COX18 cause a mitochondrial disorder primarily manifesting as peripheral neuropathy.Brain : a journal of neurology · 2026Article
- Mechanisms underlying the inhibitory effects of linalool on Aspergillus flavus spore germination.Applied microbiology and biotechnology · 2022Article
- Fates of Sec, Tat, and YidC Translocases in Mitochondria and Other Eukaryotic Compartments.Molecular biology and evolution · 2021Review
- Analysis of translating mitoribosome reveals functional characteristics of translation in mitochondria of fungi.Nature communications · 2020Article
- The Conserved Role of YidC in Membrane Protein Biogenesis.Microbiology spectrum · 2019Article
- Human mitochondrial cytochromeThe Journal of biological chemistry · 2017Article
- Mitochondrial OXA Translocase Plays a Major Role in Biogenesis of Inner-Membrane Proteins.Cell metabolism · 2016Article
- YidC/Alb3/Oxa1 Family of Insertases.The Journal of biological chemistry · 2015Review
- Arabidopsis thaliana Oxa proteins locate to mitochondria and fulfill essential roles during embryo development.Planta · 2013Article
- Mitochondrial protein synthesis, import, and assembly.Genetics · 2012Article
- Multiple roles of the Cox20 chaperone in assembly of Saccharomyces cerevisiae cytochrome c oxidase.Genetics · 2012Article
- In silico survey of the mitochondrial protein uptake and maturation systems in the brown alga Ectocarpus siliculosus.PloS one · 2011Article
- Biogenesis of bacterial inner-membrane proteins.Cellular and molecular life sciences : CMLS · 2010Review
- The C terminus of the Alb3 membrane insertase recruits cpSRP43 to the thylakoid membrane.The Journal of biological chemistry · 2010Article
- The evolution of YidC/Oxa/Alb3 family in the three domains of life: a phylogenomic analysis.BMC evolutionary biology · 2009Article
- Article
- Independent gene duplications of the YidC/Oxa/Alb3 family enabled a specialized cotranslational function.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Roles of Oxa1-related inner-membrane translocases in assembly of respiratory chain complexes.Biochimica et biophysica acta · 2009Review
- Oxa1 directly interacts with Atp9 and mediates its assembly into the mitochondrial F1Fo-ATP synthase complex.Molecular biology of the cell · 2007Article
- One of two alb3 proteins is essential for the assembly of the photosystems and for cell survival in Chlamydomonas.The Plant cell · 2006Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteins of the Oxa1/YidC/Alb3 family mediate the insertion of proteins into membranes of mitochondria, bacteria, and chloroplasts. Here we report the identification of a second gene of the Oxa1/YidC/Alb3 family in the genome of Neurospora crassa, which we have named oxa2. Its gene product, Oxa2, is located in the inner membrane of mitochondria. Deletion of the oxa2 gene caused a specific defect in the biogenesis of cytochrome oxidase and resulted in induction of the alternative oxidase (AOD), which bypasses the need for complex IV of the respiratory chain. The Oxa2 protein of N. crassa complements Cox18-deficient yeast mutants suggesting a common function for both proteins. The oxa2 sequence allowed the identification of a new subfamily of Oxa1/YidC/Alb3 proteins whose members appear to be ubiquitously present in mitochondria of fungi, plants, and animals including humans.
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