ArticleProceedings of the National Academy of Sciences of the United States of America2004
Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- Advance in Iron Metabolism, Oxidative Stress and Cellular Dysfunction in Experimental and Human Kidney Diseases.Antioxidants (Basel, Switzerland) · 2024Review
- Prolonged ethanol exposure modulates constitutive internalization and recycling of 5-HT1A receptors.Journal of neurochemistry · 2022Article
- The Bump-and-Hole Tactic: Expanding the Scope of Chemical Genetics.Cell chemical biology · 2018Review
- IQGAP1 promotes CXCR4 chemokine receptor function and trafficking via EEA-1+ endosomes.The Journal of cell biology · 2015Article
- The role of the cytoskeleton and molecular motors in endosomal dynamics.Seminars in cell & developmental biology · 2014Review
- Functions of class V myosins in neurons.The Journal of biological chemistry · 2013Review
- Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol.Proceedings of the National Academy of Sciences of the United States of America · 2010Review
- Unconventional myosins acting unconventionally.Trends in cell biology · 2009Review
- Neuroscience: Along memory lane.Nature · 2008Article
- Rapid recycling of beta-adrenergic receptors is dependent on the actin cytoskeleton and myosin Vb.Traffic (Copenhagen, Denmark) · 2008Article
- Article
- Myosin-Vb functions as a dynamic tether for peripheral endocytic compartments during transferrin trafficking.BMC cell biology · 2008Article
- Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3.Molecular biology of the cell · 2007Article
- CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling.Molecular biology of the cell · 2005Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Selective, in situ inhibition of individual unconventional myosins is a powerful approach to determine their specific physiological functions. Here, we report the engineering of a myosin Vb mutant that still hydrolyzes ATP, yet is selectively sensitized to an N(6)-substituted ADP analog that inhibits its activity, causing it to remain tightly bound to actin. Inhibition of the sensitized mutant causes inhibition of accumulation of transferrin in the cytoplasm and increases levels of plasma-membrane transferrin receptor, suggesting that myosin Vb functions in traffic between peripheral and pericentrosomal compartments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.