ArticleProceedings of the National Academy of Sciences of the United States of America2004
The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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Who cites it
73 citing papers in PubMed, 188 citations in OpenAlex.
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- Exploring Oxylipins in Host-Microbe Interactions and Their Impact on Infection and Immunity.Current issues in molecular biology · 2025Review
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- M1 macrophage inhibits ferroptosis inFrontiers in cell and developmental biology · 2025Article
- Lipoxygenases at the Intersection of Infection and Carcinogenesis.International journal of molecular sciences · 2024Review
- Biofilm-derived oxylipin 10-HOME-mediated immune response in women with breast implants.The Journal of clinical investigation · 2023Article
- Promising Anti-Inflammatory Tools: Biomedical Efficacy of Lipoxins and Their Synthetic Pathways.International journal of molecular sciences · 2023Review
- Ferroptosis: From regulation of lipid peroxidation to the treatment of diseases.Cell biology and toxicology · 2023Review
- Synbiotic Compositions ofNutrients · 2022Article
- Fungal and bacterial oxylipins are signals for intra- and inter-cellular communication within plant disease.Frontiers in plant science · 2022Review
- Ferroptosis: A mixed blessing for infectious diseases.Frontiers in pharmacology · 2022Review
- Role of Host and Bacterial Lipids inFrontiers in immunology · 2022Review
- Molecular Mechanisms of Lipid Metabolism Disorders in Infectious Exacerbations of Chronic Obstructive Pulmonary Disease.International journal of molecular sciences · 2021Review
- Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms.NPJ biofilms and microbiomes · 2021Article
- Ferroptosis: mechanisms, biology and role in disease.Nature reviews. Molecular cell biology · 2021Review
- Evidences for antioxidant response and biosorption potential of Bacillus simplex strain 115 against lead.World journal of microbiology & biotechnology · 2021Article
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- Lipoxin A4 promotes reduction and antibiotic efficacy against Pseudomonas aeruginosa biofilm.Prostaglandins & other lipid mediators · 2021Article
- Pro-Resolving Ligands Orchestrate Phagocytosis.Frontiers in immunology · 2021Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
In mammals, lipoxygenases play key roles in inflammation by initiating the transformation of arachidonic acid into potent bioactive lipid mediators such as leukotrienes and lipoxins. In general, most bacteria are believed to lack lipoxygenases and their polyunsaturated fatty acid substrates. It is therefore of interest that an ORF (PA1169) with high homology to eukaryotic lipoxygenases was discovered by analysis of the whole-genome sequence of the opportunistic bacterial pathogen Pseudomonas aeruginosa. Using TLC and liquid chromatography-UV-tandem mass spectrometry (LC-UV-MS-MS), we demonstrate that PA1169 encodes a bacterial lipoxygenase (LoxA) that converts arachidonic acid into 15-hydroxyeicosatetraenoic acid (15-HETE). Although mammalian lipoxygenases are cytoplasmic enzymes, P. aeruginosa LoxA activity is secreted. Taken together, these results suggest a mechanism by which a pathogen-secreted lipoxygenase may modulate host defense and inflammation via alteration of the biosynthesis of local chemical mediators.
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Registered trials
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