Evidence map›Paper›PMID 14766942›Full record

Trial reportThe Journal of physiology2004

Leukocytes, cytokines, growth factors and hormones in human skeletal muscle and blood after uphill or downhill running.

Christer Malm, The Late Bertil Sjödin, Berit Sjöberg, Rodica Lenkei, Per Renström, Ingrid E Lundberg, Björn Ekblom

Open access · bronzeAbstract readClinical TrialRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 297 citations in OpenAlex.

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51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Christer MalmDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. Christer.malm@anatomy.umu.se
The Late Bertil Sjödin
Berit Sjöberg
Rodica Lenkei
Per Renström
Ingrid E Lundberg
Björn Ekblom
Karolinska Institutet · SESaint Göran Hospital · SESwedish School of Sport and Health Sciences · SEUmeå University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Muscular adaptation to physical exercise has previously been described as a repair process following tissue damage. Recently, evidence has been published to question this hypothesis. The purpose of this study was to investigate inflammatory processes in human skeletal muscle and epimysium after acute physical exercise with large eccentric components. Three groups of subjects (n= 19) performed 45 min treadmill running at either 4 deg (n= 5) or 8 deg (n= 9) downhill or 4 deg uphill (n= 5) and one group served as control (n= 9). One biopsy was taken from each subject 48 h post exercise. Blood samples were taken up to 7 days post exercise. Compared to the control group, none of the markers of inflammation in muscle and epimysium samples was different in any exercised group. Only subjects in the Downhill groups experienced delayed onset of muscle soreness (DOMS) and increased serum creatine kinase activity (CK). The detected levels of immunohistochemical markers for T cells (CD3), granulocytes (CD11b), leukaemia inhibitory factor (LIF) and hypoxia-inducible factor 1beta (HIF-1beta) were greater in epimysium from exercised subjects with DOMS ratings >3 (0-10 scale) compared to exercised subjects without DOMS but not higher than controls. Eccentric physical exercise (downhill running) did not result in skeletal muscle inflammation 48 h post exercise, despite DOMS and increased CK. It is suggested that exercise can induce DOMS by activating inflammatory factors present in the epimysium before exercise. Repeated physical training may alter the content of inflammatory factors in the epimysium and thus reduce DOMS.

Indexed as

AdolescentAdultAntigens, CDAntigens, Differentiation, MyelomonocyticAryl Hydrocarbon Receptor Nuclear TranslocatorCD11b AntigenCD163 AntigenCD3 ComplexCD56 AntigenC-Reactive ProteinCreatine KinaseCytokinesDNA-Binding ProteinsExercise TestFasciafas ReceptorAntigens, CDAntigens, Differentiation, MyelomonocyticARNT protein, humanAryl Hydrocarbon Receptor Nuclear TranslocatorCD11b AntigenCD163 AntigenCD3 ComplexCD56 AntigenC-Reactive ProteinCreatine KinaseCytokinesDNA-Binding Proteinsfas ReceptorGrowth SubstancesHormonesInsulin-Like Growth Factor IInterleukin-6Ki-67 AntigenLeukemia Inhibitory FactorLeukemia Inhibitory Factor Receptor alpha SubunitLIF protein, humanLIFR protein, humanProteinsReceptors, Aryl HydrocarbonReceptors, Cell SurfaceReceptors, CytokineReceptors, OSM-LIFTestosteroneTranscription Factors

Identifiers

PMID14766942
PMCPMC1664987
OpenAlexW2171507288

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.