ArticleJournal of clinical microbiology2004
Determination of infectious load of Mycoplasma genitalium in clinical samples of human vaginal cells.
Article in Journal of clinical microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- Subversion of the Immune Response by Human Pathogenic Mycoplasmas.Frontiers in microbiology · 2019Review
- The Immunopathogenesis of Mycoplasma genitalium Infections in Women: A Narrative Review.Sexually transmitted diseases · 2017Review
- Evaluation of the Hologic Panther Transcription-Mediated Amplification Assay for Detection of Mycoplasma genitalium.Journal of clinical microbiology · 2016Article
- Clinical Laboratory Assessment of Mycoplasma genitalium Transcription-Mediated Amplification Using Primary Female Urogenital Specimens.Journal of clinical microbiology · 2016Article
- The prevalence of urethral and rectal Mycoplasma genitalium among men who have sex with men in China, a cross-sectional study.BMC public health · 2014Article
- Mycoplasma genitalium infection activates cellular host defense and inflammation pathways in a 3-dimensional human endocervical epithelial cell model.The Journal of infectious diseases · 2013Article
- Natural history of Mycoplasma genitalium infection in a cohort of female sex workers in Kampala, Uganda.Sexually transmitted diseases · 2013Article
- Mycoplasma genitalium: an emerging sexually transmitted pathogen.The Indian journal of medical research · 2012Review
- Persistent Mycoplasma genitalium infection of human endocervical epithelial cells elicits chronic inflammatory cytokine secretion.Infection and immunity · 2012Article
- Mycoplasma genitalium: from Chrysalis to multicolored butterfly.Clinical microbiology reviews · 2011Review
- Comparison of two Mycoplasma genitalium real-time PCR detection methodologies.Journal of clinical microbiology · 2011Article
- Transcriptional response of Mycoplasma genitalium to osmotic stress.Microbiology (Reading, England) · 2011Article
- Molecular cloning, expression, and characterization of a Ca2+-dependent, membrane-associated nuclease of Mycoplasma genitalium.Journal of bacteriology · 2010Article
- Article
- Mycoplasma gallisepticum invades chicken erythrocytes during infection.Infection and immunity · 2008Article
- Comparison of transcription-mediated amplification and PCR assay results for various genital specimen types for detection of Mycoplasma genitalium.Journal of clinical microbiology · 2006Article
- Performance of the gen-probe transcription-mediated [corrected] amplification research assay compared to that of a multitarget real-time PCR for Mycoplasma genitalium detection.Journal of clinical microbiology · 2006Article
- Transcriptional heat shock response in the smallest known self-replicating cell, Mycoplasma genitalium.Journal of bacteriology · 2006Article
- Proximal region of the gene encoding cytadherence-related protein permits molecular typing of Mycoplasma genitalium clinical strains by PCR-restriction fragment length polymorphism.Journal of clinical microbiology · 2006Article
- Chlamydial plasmid-encoded virulence factor Pgp3 interacts with human cathelicidin peptide LL-37 to modulate immune response.Microbes and infectionArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Mycoplasma genitalium is a leading cause of chlamydia-negative, nongonoccocal urethritis and has been directly implicated in numerous other genitourinary as well as extragenitourinary tract pathologies. Detection of M. genitalium has relied almost entirely on PCR amplification of clinical specimens and evidence of seroconversion since these mycoplasmas are highly fastidious and culture isolation by microbiological techniques is very rare. We have established a combinatorial strategy using confocal immunoanalysis (CIA) and real-time PCR to qualitatively and quantitatively assess patterns of M. genitalium infection in women attending a sexually transmitted disease-related health clinic in San Antonio, Tex. CIA allows spatial examination of mycoplasmas on surfaces and inside human target cells, plus the ability to evaluate cell-to-cell patterns and variances within samples. Real-time PCR permits determination of genome copy numbers of mycoplasmas and human cells by multiplex amplification using mycoplasma gyrA and human RNase P gene sequences, which indicates overall levels of mycoplasma infection and degree of parasitism. These assays are strongly correlated and, in combination, permit detection and elucidation of heretofore-unrecognized patterns of M. genitalium infections in clinical and experimental samples.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.