ArticleThe EMBO journal2004
Formation, maintenance and consequences of the imprint at the mating-type locus in fission yeast.
Article in The EMBO journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 54 citations in OpenAlex.
- Homologous recombination mutants cause differing lethality between h- and h+ Schizosaccharomyces pombe strains due to mat1 heterochromatin.The FEBS journal · 2026Article
- Genetic and Epigenetic Mechanisms Underlying Reversible Adaptive Responses in Fungi.Journal of fungi (Basel, Switzerland) · 2026Review
- The Fission Yeast Mating-Type Switching Motto: "One-for-Two" and "Two-for-One".Microbiology and molecular biology reviews : MMBR · 2023Review
- Article
- Review
- New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.PLoS genetics · 2018Article
- Molecular signature of the imprintosome complex at the mating-type locus in fission yeast.Microbial cell (Graz, Austria) · 2018Article
- Review
- Swi1Timeless Prevents Repeat Instability at Fission Yeast Telomeres.PLoS genetics · 2016Article
- A Unique DNA Recombination Mechanism of the Mating/Cell-type Switching of Fission Yeasts: a Review.Microbiology spectrum · 2014Review
- Two portable recombination enhancers direct donor choice in fission yeast heterochromatin.PLoS genetics · 2013Article
- Replication fork stability is essential for the maintenance of centromere integrity in the absence of heterochromatin.Cell reports · 2013Article
- Defining the epigenetic mechanism of asymmetric cell division of Schizosaccharomyces japonicus yeast.Genetics · 2013Article
- Lsd1 and lsd2 control programmed replication fork pauses and imprinting in fission yeast.Cell reports · 2012Article
- Local and global functions of Timeless and Tipin in replication fork protection.Cell cycle (Georgetown, Tex.) · 2012Review
- Identification of a novel type of spacer element required for imprinting in fission yeast.PLoS genetics · 2011Article
- Checkpoint-dependent and -independent roles of Swi3 in replication fork recovery and sister chromatid cohesion in fission yeast.PloS one · 2010Article
- Comparative genomics and molecular dynamics of DNA repeats in eukaryotes.Microbiology and molecular biology reviews : MMBR · 2008Review
- Mus81 is essential for sister chromatid recombination at broken replication forks.The EMBO journal · 2008Article
- Schizosaccharomyces pombe switches mating type by the synthesis-dependent strand-annealing mechanism.Genetics · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mating-type switching in the fission yeast Schizosaccharomyces pombe is initiated by a strand-specific imprint located at the mating-type (mat1) locus. We show that the imprint corresponds to a single-strand DNA break (SSB), which is site- but not sequence-specific. We identified three novel cis-acting elements, involved in the formation and stability of the SSB. One of these elements is essential for a replication fork pause next to mat1 and interacts in vivo with the Swi1 protein. Another element is essential for maintaining the SSB during cell cycle progression. These results suggest that the DNA break appears during the S-phase and is actively protected against repair. Consequently, during the following round of replication, a polar double-strand break is formed. We show that when the replication fork encounters the SSB, the leading-strand DNA polymerase is able to synthesize DNA to the edge of the SSB, creating a blunt-ended recombination intermediate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.