ArticleNucleic acids research2004
Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation.
Article in Nucleic acids research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Replication fork slowing and stalling are distinct, checkpoint-independent consequences of replicating damaged DNA.PLoS genetics · 2017Article
- Effective intra-S checkpoint responses to UVC in primary human melanocytes and melanoma cell lines.Pigment cell & melanoma research · 2016Article
- Checkpoint regulation of replication forks: global or local?Biochemical Society transactions · 2013Review
- Article
- WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes.Journal of cell science · 2011Article
- Targeted deletion of mouse Rad1 leads to deficient cellular DNA damage responses.Protein & cell · 2011Article
- The human intra-S checkpoint response to UVC-induced DNA damage.Carcinogenesis · 2010Review
- PARP-1 ensures regulation of replication fork progression by homologous recombination on damaged DNA.The Journal of cell biology · 2008Article
- The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses.Molecular and cellular biology · 2007Article
- The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement.Molecular and cellular biology · 2007Article
- Increased common fragile site expression, cell proliferation defects, and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells.Molecular biology of the cell · 2007Article
- Genome maintenance defects in cultured cells and mice following partial inactivation of the essential cell cycle checkpoint gene Hus1.Molecular and cellular biology · 2007Article
- Functional interactions of DNA topoisomerases with a human replication origin.The EMBO journal · 2007Article
- Integrating S-phase checkpoint signaling with trans-lesion synthesis of bulky DNA adducts.Cell biochemistry and biophysics · 2007Review
- Article
- cAMP-mediated inhibition of DNA replication and S phase progression: involvement of Rb, p21Cip1, and PCNA.Molecular biology of the cell · 2005Article
- DNA damage checkpoint responses in the S phase of synchronized diploid human fibroblasts.Photochemistry and photobiologyArticle
Corrections and comments
- Retraction · 2020-02-25Duplication of/in Image ·
- Retracted
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
DNA damage-induced S phase (S) checkpoint includes inhibition of both replicon initiation and chain elongation. The precise mechanism for controlling the two processes remains unclear. In this study, we showed that Hus1-deficient mouse cells had an impaired S checkpoint after exposure to DNA strand break-inducing agents such as camptothecin (CPT) (>or=1.0 micro M), or ionizing radiation (IR) (>or=15 Gy). The Hus1-dependent S checkpoint contributes to cell resistance to CPT. This impaired S checkpoint induced by CPT or IR in Hus1-deficient cells reflected mainly the chain elongation step of DNA replication and was correlated with the reduction of dissociation of PCNA from DNA replication foci. Although Hus1 is required for Rad9 phosphorylation following exposure of cells to CPT or IR, Hus1-deficient cells showed normal activation of ATR/CHK1 and ATM kinases at doses where the checkpoint defects were manifested, suggesting that Hus1 is not a component of the sensor system for activating these pathways in S checkpoint induced by CPT or IR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.