ArticleProceedings of the National Academy of Sciences of the United States of America2004
B cell development and immunoglobulin transcription in Oct-1-deficient mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Functional Elucidation ofInsects · 2025Article
- The Oct1 transcription factor and epithelial malignancies: Old protein learns new tricks.Biochimica et biophysica acta · 2016Review
- Octamer transcription factor 1 mediates epithelial-mesenchymal transition in colorectal cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Article
- OCT-1 overexpression is associated with poor prognosis in patients with well-differentiated gastric cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Oct-1 regulates IL-17 expression by directing interchromosomal associations in conjunction with CTCF in T cells.Molecular cell · 2014Article
- The Oct1 homolog Nubbin is a repressor of NF-κB-dependent immune gene expression that increases the tolerance to gut microbiota.BMC biology · 2013Article
- Octamer-binding transcription factors: genomics and functions.Frontiers in bioscience (Landmark edition) · 2013Review
- Article
- Octamer-dependent transcription in T cells is mediated by NFAT and NF-κB.Nucleic acids research · 2013Article
- Transcription factor Oct1 is a somatic and cancer stem cell determinant.PLoS genetics · 2012Article
- Oct1 is a switchable, bipotential stabilizer of repressed and inducible transcriptional states.The Journal of biological chemistry · 2011Article
- Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity.Nature cell biology · 2009Article
- A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress.Genes & development · 2009Article
- Characterization of an Oct1 orthologue in the channel catfish, Ictalurus punctatus: a negative regulator of immunoglobulin gene transcription?BMC molecular biology · 2007Article
- A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory.The EMBO journal · 2006Article
- Identification of novel genes and transcription factors involved in spleen, thymus and immunological development and function.Genes and immunity · 2006Article
- The POU transcription factor Oct-1 represses virus-induced interferon A gene expression.Molecular and cellular biology · 2005Article
- Predictive screening for regulators of conserved functional gene modules (gene batteries) in mammals.BMC genomics · 2005Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The POU domain transcription factors Oct-1 and Oct-2 interact with the octamer element, a motif conserved within Ig promoters and enhancers, and mediate transcription from the Ig loci. Inactivation of Oct-2 by gene targeting results in normal B cell development and Ig transcription. To study the role of Oct-1 in these processes, the lymphoid compartment of RAG-1(-/-) animals was reconstituted with Oct-1-deficient fetal liver hematopoietic cells. Recipient mice develop B cells with levels of surface Ig expression comparable with wild type, although at slightly reduced numbers. These B cells transcribe Ig normally, respond to antigenic stimulation, undergo class switching, and use a normal repertoire of light chain variable segments. However, recipient mice show slight reductions in serum IgM and IgA. Thus, the Oct-1 protein is dispensable for B cell development and Ig transcription.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.