ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
A novel cAMP-dependent pathway activates neuronal integrin function in retinal neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- The cAMP Inducers ModifyAntioxidants (Basel, Switzerland) · 2021Article
- Functional polarization of human hepatoma HepaRG cells in response to forskolin.Scientific reports · 2018Article
- An Overview of Neural Differentiation Potential of Human Adipose Derived Stem Cells.Stem cell reviews and reports · 2016Review
- Comparison of sensory neuron growth cone and filopodial responses to structurally diverse aggrecan variants, in vitro.Experimental neurology · 2013Article
- Protein kinase A and C regulate leak potassium currents in freshly isolated vascular myocytes from the aorta.PloS one · 2013Article
- Ras-associating domain proteins: a new class of cyclic nucleotide-gated channel modulators.Advances in experimental medicine and biology · 2012Article
- β1 integrin-focal adhesion kinase (FAK) signaling modulates retinal ganglion cell (RGC) survival.PloS one · 2012Article
- ACTH induces Cav3.2 current and mRNA by cAMP-dependent and cAMP-independent mechanisms.The Journal of biological chemistry · 2010Article
- cAMP analogs and their metabolites enhance TREK-1 mRNA and K+ current expression in adrenocortical cells.Molecular pharmacology · 2010Article
- N6-substituted cAMP analogs inhibit bTREK-1 K+ channels and stimulate cortisol secretion by a protein kinase A-independent mechanism.Molecular pharmacology · 2009Article
- ACTH inhibits bTREK-1 K+ channels through multiple cAMP-dependent signaling pathways.The Journal of general physiology · 2008Article
- Rac1 and RhoA promote neurite outgrowth through formation and stabilization of growth cone point contacts.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Semaphorins command cells to move.Nature reviews. Molecular cell biology · 2005Review
- Chronic enhancement of the intrinsic growth capacity of sensory neurons combined with the degradation of inhibitory proteoglycans allows functional regeneration of sensory axons through the dorsal root entry zone in the mammalian spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Tissue inhibitor of metalloproteinase-2 promotes neuronal differentiation by acting as an anti-mitogenic signal.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retinal neurons lose the ability to attach to and extend neurites on substrata of laminin-1 (LN-1) during late embryogenesis, in a time frame that corresponds to target innervation. Although this developmental loss correlates with a modest downregulation of integrin expression, we have shown previously that these neurons use the same laminin-binding integrins for outgrowth on other laminin isoforms to which responsivity has not been lost (Ivins et al., 1998), suggesting that integrin functional states may be a critical point of regulation. Consistent with this view, expression of an activated mutant of R-ras, an activator of integrin function, restores integrin-dependent outgrowth of late embryonic retinal neurons on LN-1 (Ivins et al., 2000). Because cyclic nucleotides have been implicated in the regulation of integrin function in non-neuronal cells, as well as in the regulation of growth cone responses to various axon growth inhibitors, we asked whether raising cAMP levels in late embryonic retinal neurons could activate neuronal integrin function and restore neurite outgrowth on LN-1. We find that, similar to R-ras expression, raising cAMP levels in these neurons promotes alpha6beta1 integrin-dependent neurite outgrowth. Surprisingly, these effects of cAMP are independent of protein kinase A and the EPAC (exchange protein directly activated by cAMP)/Rap pathway and suggest the existence of a novel cAMP-dependent mechanism.
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