ArticleGenome research2004
A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 21q.
Article in Genome research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 169 citations in OpenAlex.
- Cell-free placental DNA: What do we really know?PLoS genetics · 2024Review
- CMIC: predicting DNA methylation inheritance of CpG islands with embedding vectors of variable-length k-mers.BMC bioinformatics · 2022Article
- Current and Emerging Technologies for the Analysis of the Genome-Wide and Locus-Specific DNA Methylation Patterns.Advances in experimental medicine and biology · 2022Article
- Upregulated PPARG2 facilitates interaction with demethylated AKAP12 gene promoter and suppresses proliferation in prostate cancer.Cell death & disease · 2021Article
- DNA methylation methods: Global DNA methylation and methylomic analyses.Methods (San Diego, Calif.) · 2021Review
- DNA methylation studies in cattle.Journal of applied genetics · 2021Review
- A method for identifying allele-specific hydroxymethylation.Epigenetics · 2020Article
- Article
- Insights into Epigenome Evolution from Animal and Plant Methylomes.Genome biology and evolution · 2017Article
- Factors to preserve CpG-rich sequences in methylated CpG islands.BMC genomics · 2015Article
- Analysis of the leaf methylomes of parents and their hybrids provides new insight into hybrid vigor in Populus deltoides.BMC genetics · 2014Article
- Not so pseudo: the evolutionary history of protein phosphatase 1 regulatory subunit 2 and related pseudogenes.BMC evolutionary biology · 2013Article
- Research progress in allele-specific expression and its regulatory mechanisms.Journal of applied genetics · 2013Review
- CpGIMethPred: computational model for predicting methylation status of CpG islands in human genome.BMC medical genomics · 2013Article
- Article
- Genome-wide genetic variations are highly correlated with proximal DNA methylation patterns.Genome research · 2012Article
- A genetic association study of DNA methylation levels in the DRD4 gene region finds associations with nearby SNPs.Behavioral and brain functions : BBF · 2012Article
- Cytosine methylation in miR-153 gene promoters increases the expression of holocarboxylase synthetase, thereby increasing the abundance of histone H4 biotinylation marks in HEK-293 human kidney cells.The Journal of nutritional biochemistry · 2012Article
- High resolution methylome map of rat indicates role of intragenic DNA methylation in identification of coding region.PloS one · 2012Article
- Clustered transcripts that escape X inactivation at mouse XqD.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Approximately half of all human genes have CpG islands (CGIs)around their promoter regions. Although CGIs usually escape methylation, those on Chromosome X in females and those in the vicinity of imprinted genes are exceptions: They have both methylated and unmethylated alleles to display a "composite" pattern in methylation analysis. In addition, aberrant methylation of CGIs is known to often occur in cancer cells. Here we developed a simple HpaII-McrBC PCR method for discrimination of full, null, incomplete, and composite methylation patterns, and applied it to all computationally identified CGIs on human Chromosome 21q. This comprehensive analysis revealed that, although most CGIs (103 out of 149)escape methylation, a sizable fraction (31 out of 149)are fully methylated even in normal peripheral blood cells. Furthermore, we identified seven CGIs showing the composite methylation, and demonstrated that three of them are indeed methylated monoallelically. Further analyses using informative pedigrees revealed that two of the three are subject to maternal allele-specific methylation. Intriguingly, the other CGI is methylated in an allele-specific but parental-origin-independent manner. Thus, the cell seems to have a broader repertoire of methylating CGIs than previously thought, and our approach may contribute to uncover novel modes of allelic methylation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.