ArticleWorld journal of gastroenterology2004
Striking elevation in incidence and prevalence of inflammatory bowel disease in a province of western Hungary between 1977-2001.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 141 citations in OpenAlex.
- Inflammatory bowel diseases in the elderly population: epidemiology, long-term disease course, surgery rates, and biological use-data from the Veszprem county cohort between 1977 and 2020.Journal of Crohn's & colitis · 2025Article
- Declining Trends of Reoperations and Disease Behaviour Progression in Crohn's Disease over Different Therapeutic Eras-A Prospective, Population-Based Study from Western Hungary between 1977-2020, Data from the Veszprem Cohort.Journal of Crohn's & colitis · 2023Article
- Establishment of a lipopolysaccharide-induced inflammation model of human fetal colon cells.Molecular biology reports · 2023Article
- Time Trends of Environmental and Socioeconomic Risk Factors in Patients with Inflammatory Bowel Disease over 40 Years: A Population-Based Inception Cohort 1977-2020.Journal of clinical medicine · 2023Article
- Graphene oxide exacerbates dextran sodium sulfate-induced colitis via ROS/AMPK/p53 signaling to mediate apoptosis.Journal of nanobiotechnology · 2021Article
- The four epidemiological stages in the global evolution of inflammatory bowel disease.Nature reviews. Gastroenterology & hepatology · 2021Review
- The first step to unveil the epidemiology of inflammatory bowel disease in Central Asia.Intestinal research · 2020Article
- Opening a Window on Attention: Adjuvant Therapies for Inflammatory Bowel Disease.Canadian journal of gastroenterology & hepatology · 2020Review
- Observational
- Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses.The Journal of biological chemistry · 2016Article
- Environmental risk factors for inflammatory bowel diseases: Evidence based literature review.World journal of gastroenterology · 2016Review
- Host-microbiome interaction in Crohn's disease: A familiar or familial issue?World journal of gastrointestinal pathophysiology · 2015Review
- Prevalence and predictors of hospitalization in Crohn's disease in a prospective population-based inception cohort from 2000-2012.World journal of gastroenterology · 2015Observational
- A retrospective, case-control study on traditional environmental risk factors in inflammatory bowel disease in Vukovar-Srijem County, north-eastern Croatia, 2010.Wiener klinische Wochenschrift · 2015Article
- Biological therapy in inflammatory bowel diseases: access in Central and Eastern Europe.World journal of gastroenterology · 2015Review
- Personalized management of IBD; is there any practical approach?Gastroenterology and hepatology from bed to bench · 2015Article
- Epidemiology, demographic characteristics and prognostic predictors of ulcerative colitis.World journal of gastroenterology · 2014Review
- NOD2 gene mutations in ulcerative colitis: useless or misunderstood?International journal of colorectal disease · 2014Article
- MiR-29a promotes intestinal epithelial apoptosis in ulcerative colitis by down-regulating Mcl-1.International journal of clinical and experimental pathology · 2014Article
- Is early limited surgery associated with a more benign disease course in Crohn's disease?World journal of gastroenterology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimAn investigation into inflammatory bowel disease and colorectal cancer in Veszprem Province was conducted from 1977 to 2001.
methodsBoth hospital and outpatient records were collected and reviewed comprehensively. The majority of patients were followed up regularly.
resultsThe population of the province was decreased from 386,000 to 376,000 during the period. Five hundred sixty new cases of ulcerative colitis (UC), 212 of Crohn's disease (CD), and 40 of indeterminate colitis (IC) were diagnosed. The incidence rates increased from 1.66 to 11.01 cases per 100,000 persons for UC, from 0.41 to 4.68 for CD and from 0.26 to 0.74 for IC. The prevalence rate at the end of 2001 was 142.6 for UC and 52.9 cases per 100,000 persons for CD. The peak onset age in UC patients was between 30 and 40 years, in CD between 20 and 30 years. A family history of IBD was present in 3.4 % in UC and 9.9 % in CD patients. Smoking increased the risk for CD (OR=1.98) while it decreased the risk for UC (OR=0.25). Twelve colorectal carcinomas were observed in this cohort, the cumulative colorectal cancer risk after 10 years in UC was 2%, after 20 years 8.8%, after 30 years 13.3%.
conclusionThe incidence and prevalence rates of IBD have increased steadily in Veszprem Province, now equivalent to that in Western European countries. Rapid increase in incidence rates supports a probable role for environmental factors. The rate of colorectal cancers in IBD is similar to that observed in Western countries.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.