ArticleWorld journal of gastroenterology2004
Hemizygous deletion and hypermethylation of RUNX3 gene in hepatocellular carcinoma.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Clinicopathological significance of RUNX3 gene hypermethylation in hepatocellular carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Review
- Epigenetic Abnormalities in Chondrosarcoma.International journal of molecular sciences · 2023Review
- Complex Interplay between the RUNX Transcription Factors and Wnt/β-Catenin Pathway in Cancer: A Tango in the Night.Molecules and cells · 2020Review
- Transcriptome changes induced byOncology letters · 2020Article
- Loss of RUNX3 is significantly associated with advanced tumor grade and stage in endometrial cancers.Molecular medicine reports · 2018Article
- Epigenetic inactivation ofAnnals of surgical treatment and research · 2018Article
- Truncated forms of RUNX3 Unlike Full Length Protein Alter Cell Proliferation in a TGF-β Context Dependent Manner.Iranian journal of pharmaceutical research : IJPR · 2017Article
- Epigenetic mechanisms regulating the development of hepatocellular carcinoma and their promise for therapeutics.Hepatology international · 2017Review
- Loss of Runt-related transcription factor 3 induces resistance to 5-fluorouracil and cisplatin in hepatocellular carcinoma.Oncology reports · 2016Article
- Targeting of RUNX3 by miR-130a and miR-495 cooperatively increases cell proliferation and tumor angiogenesis in gastric cancer cells.Oncotarget · 2015Article
- Altered placental DNA methylation patterns associated with maternal smoking: current perspectives.Advances in genomics and genetics · 2015Article
- EZH2 elevates the proliferation of human cholangiocarcinoma cells through the downregulation of RUNX3.Medical oncology (Northwood, London, England) · 2014Article
- Loss of RUNX3 expression may contribute to poor prognosis in patients with chondrosarcoma.Journal of molecular histology · 2013Article
- Placental DNA methylation alterations associated with maternal tobacco smoking at the RUNX3 gene are also associated with gestational age.Epigenomics · 2013Article
- DNA methylation of RUNX3 in papillary thyroid cancer.The Korean journal of internal medicine · 2012Article
- RUNX3 expression is lost in glioma and its restoration causes drastic suppression of tumor invasion and migration.Journal of cancer research and clinical oncology · 2011Article
- Loss of RUNX3 expression by histone deacetylation is associated with biliary tract carcinogenesis.Cancer science · 2011Article
- Loss of runt-related transcription factor 3 expression leads hepatocellular carcinoma cells to escape apoptosis.BMC cancer · 2011Article
- Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer.Oncogene · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo analyze the genetic and epigenetic alterations of RUNX3 gene, a potential putative tumor suppressor gene, in hepatocellular carcinoma (HCC).
methodsPCR-based loss of heterozygosity (LOH) detection, analysis of mutation with PCR-single strand conformational polymorphism (SSCP) and sequencing, and methylation study with methylation specific PCR (MSP) were performed on RUNX3 gene in a series of 62 HCCs along with their matched normal tissues.
resultsMutation of RUNX3 gene was not found, but one single nucleotide polymorphism with T to A transversion at the second nucleotide of the 18th codon was found. Nine of 26 informative cases (34.6%) showed allelic loss on the polymorphic site and 30 cases (48.4%) revealed hypermethylation of RUNX3 gene in promoter CpG islands. Furthermore, of the 9 cases with LOH, 8 (88.9%) also had hypermethylation.
conclusionOur findings indicate that inactivation of RUNX3 gene through allelic loss and promoter hypermethylation might be one of the major mechanisms in hepatocellular carcinogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.