ArticleWorld journal of gastroenterology2004
Apoptosis of human gastric adenocarcinoma cells induced by beta-ionone.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 64 citations in OpenAlex.
- Apoptosis induced by preoperative oral 5'-DFUR administration in gastric adenocarcinoma and its mechanism of action.World journal of gastroenterology · 2006Trial
- β-ionone synergizes with 5-Fluorouracil to inhibit gastric cancer progression through PAX6-mediated cell cycle arrest.BMC cancer · 2026Article
- Widely Targeted Metabolomics ofFood science & nutrition · 2025Article
- Antioxidant Activity and Cytotoxicity Evaluation of New Catechol Hydrazinyl-Thiazole Derivatives as Potential Protectors in Retinal Degenerative Processes.Antioxidants (Basel, Switzerland) · 2025Article
- Flower Species Ingredient Verification Using Orthogonal Molecular Methods.Foods (Basel, Switzerland) · 2024Article
- Antiplasmodial Activity of β-Ionone and the Effect of the Compound on Amelioration of Anaemia and Oxidative Organ Damage in Mice Infected with Plasmodium berghei.Acta parasitologica · 2024Article
- Article
- Ionone Is More than a Violet's Fragrance: A Review.Molecules (Basel, Switzerland) · 2020Review
- Apocarotenoids: Emerging Roles in Mammals.Annual review of nutrition · 2018Article
- Proteome Changes of Human Bone Marrow Mesenchymal Stem Cells Induced by 1,4-Benzoquinone.BioMed research international · 2016Article
- γ-Tocotrienol induces paraptosis-like cell death in human colon carcinoma SW620 cells.PloS one · 2013Article
- Enzymatic formation of apo-carotenoids from the xanthophyll carotenoids lutein, zeaxanthin and β-cryptoxanthin by ferret carotene-9',10'-monooxygenase.Archives of biochemistry and biophysics · 2011Article
- Fresh raspberry phytochemical extract inhibits hepatic lesion in a Wistar rat model.Nutrition & metabolism · 2010Article
- beta-Ionone-induced apoptosis in human osteosarcoma (U2os) cells occurs via a p53-dependent signaling pathway.Molecular biology reports · 2010Article
- {beta}-Apocarotenoids do not significantly activate retinoic acid receptors {alpha} or {beta}.Experimental biology and medicine (Maywood, N.J.) · 2010Article
- Apoptotic efficacy of biogenic silver nanoparticles on human breast cancer MCF-7 cell lines.Progress in biomaterialsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effect of beta-ionone on the growth and apoptosis of gastric adenocarcinoma cell line SGC-7901.
methodsUsing MTT, fluorescence dye (Hoechst-33258), transmission electron microscopy and the TUNEL assay, we examined growth and apoptosis of SGC-7901 cells treated with beta-ionone at various concentrations (i.e. 25, 50, 100 and 200 micromol/L) for 24 h, 48 h.
resultsThe growth of SGC-7901 cells was inhibited by beta-ionone. Seven days after treatment with beta-ionone at four concentrations, the inhibition rates were 12.04%, 30.59%, 78.25% and 94.15%, respectively. The IC(50) value of beta-ionone for SGC-7901 cells was estimated to be 89 micromol/L. The apoptotic morphology was demonstrated in SGC-7901 cells treated with beta-ionone by Hoechst-33258 staining and electron microscopy. Apoptosis was also shown in beta-ionone-treated SGC-7901 cells by the TUNEL assay.
conclusionbeta-ionone can inhibit cell proliferation and induce apoptosis of SGC-7901 cells. However, the mechanism needs to be further investigated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.