ArticleInternational journal of legal medicine2004
Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians.
Article in International journal of legal medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed.
- West Eurasian mtDNA lineages in India: an insight into the spread of the Dravidian language and the origins of the caste system.Human genetics · 2015Trial
- A Rapid, Reliable and Reproducible Protocol for DNA Degradation in Genetic Applications.Cells · 2025Article
- Evaluating the suitability of current mitochondrial DNA interpretation guidelines for multigenerational whole mitochondrial genome comparisons.Journal of forensic sciences · 2022Article
- Helena's Many Daughters: More Mitogenome Diversity behind the Most Common West Eurasian mtDNA Control Region Haplotype in an Extended Italian Population Sample.International journal of molecular sciences · 2022Article
- Population inference based on mitochondrial DNA control region data by the nearest neighbors algorithm.International journal of legal medicine · 2021Article
- Complete mitogenome data for the Serbian population: the contribution to high-quality forensic databases.International journal of legal medicine · 2020Article
- Whole Mitochondrial DNA Sequencing Analysis in 47 Han Populations in Southwest China.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Recovery of whole mitochondrial genome from compromised samples via multiplex PCR and massively parallel sequencing.Future science OA · 2018Article
- Massively parallel sequencing-enabled mixture analysis of mitochondrial DNA samples.International journal of legal medicine · 2018Article
- Entire Mitochondrial DNA Sequencing on Massively Parallel Sequencing for the Korean Population.Journal of Korean medical science · 2017Article
- Forensically relevant SNaPshotInternational journal of legal medicine · 2017Review
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- Ancient inland human dispersals from Myanmar into interior East Asia since the Late Pleistocene.Scientific reports · 2015Article
- A high-throughput Sanger strategy for human mitochondrial genome sequencing.BMC genomics · 2013Article
- DNA capture and next-generation sequencing can recover whole mitochondrial genomes from highly degraded samples for human identification.Investigative genetics · 2013Article
- Genomic analysis of natural selection and phenotypic variation in high-altitude mongolians.PLoS genetics · 2013Article
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- Characterization of mtDNA variation in a cohort of South African paediatric patients with mitochondrial disease.European journal of human genetics : EJHG · 2012Article
- Current genetic methodologies in the identification of disaster victims and in forensic analysis.Journal of applied genetics · 2012Review
4 more citing papers are in PubMed but not listed here.
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
We have sequenced the entire mtDNA genome (mtGenome) of 241 individuals who match 1 of 18 common European Caucasian HV1/HV2 types, to identify sites that permit additional forensic discrimination. We found that over the entire mtGenome even individuals with the same HV1/HV2 type rarely match. Restricting attention to sites that are neutral with respect to phenotypic expression, we have selected eight panels of single nucleotide polymorphism (SNP) sites that are useful for additional discrimination. These panels were selected to be suitable for multiplex SNP typing assays, with 7-11 sites per panel. The panels are specific for one or more of the common HV1/HV2 types (or closely related types), permitting a directed approach that conserves limiting case specimen extracts while providing a maximal chance for additional discrimination. Discrimination provided by the panels reduces the frequency of the most common type in the European Caucasian population from approximately 7% to approximately 2%, and the 18 common types we analyzed are resolved to 105 different types, 55 of which are seen only once.
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