ArticleBritish journal of cancer2004
Evidence that involucrin, a marker for differentiation, is oxygen regulated in human squamous cell carcinomas.
Article in British journal of cancer, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 72 citations in OpenAlex.
- Differential roles of the type I and II secretion systems for the intracellular ABC141 Acinetobacter baumannii infection, which elicits an atypical hypoxia response in endothelial cells.PLoS pathogens · 2026Article
- Pathophysiological effects of hypoxia on testis function and spermatogenesis.Nature reviews. Urology · 2025Review
- Development and validation of cost-effective multi-sample hypoxia chambers for proton ultra-high dose rate organoid irradiations.Clinical and translational radiation oncology · 2025Article
- Spatial FAP Expression as Detected byMolecular imaging and biology · 2025Article
- Evaluating the Sub-Acute Toxicity of Formaldehyde Fumes in an In Vitro Human Airway Epithelial Tissue Model.International journal of molecular sciences · 2022Article
- PKMYT1 regulates the proliferation and epithelial-mesenchymal transition of oral squamous cell carcinoma cells by targeting CCNA2.Oncology letters · 2022Article
- High pATM is Associated With Poor Local Control in Supraglottic Cancer Treated With Radiotherapy.The Laryngoscope · 2020Article
- Identification, Validation, and Functional Annotations of Genome-Wide Profile Variation between Melanocytic Nevus and Malignant Melanoma.BioMed research international · 2020Article
- Three-dimensional alginate hydrogels for radiobiological and metabolic studies of cancer cells.Colloids and surfaces. B, Biointerfaces · 2018Article
- Transient HIF2A inhibition promotes satellite cell proliferation and muscle regeneration.The Journal of clinical investigation · 2018Article
- Aryl Hydrocarbon Receptor Nuclear Translocator in Vascular Smooth Muscle Cells Is Required for Optimal Peripheral Perfusion Recovery.Journal of the American Heart Association · 2018Article
- Hallmarks of Bone Metastasis.Calcified tissue international · 2018Review
- Quantitative imaging of pOFree radical research · 2017Article
- Modest and Severe Maternal Iron Deficiency in Pregnancy are Associated with Fetal Anaemia and Organ-Specific Hypoxia in Rats.Scientific reports · 2017Article
- A review of the development of tumor vasculature and its effects on the tumor microenvironment.Hypoxia (Auckland, N.Z.) · 2017Review
- Placental Hypoxia During Early Pregnancy Causes Maternal Hypertension and Placental Insufficiency in the Hypoxic Guinea Pig Model.Biology of reproduction · 2016Article
- Epigenetic therapy potential of suberoylanilide hydroxamic acid on invasive human non-small cell lung cancer cells.Oncotarget · 2016Article
- MicroRNA profiling of cisplatin-resistant oral squamous cell carcinoma cell lines enriched with cancer-stem-cell-like and epithelial-mesenchymal transition-type features.Scientific reports · 2016Article
- All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy.BMC complementary and alternative medicine · 2016Article
- Endothelial fibroblast growth factor receptor signaling is required for vascular remodeling following cardiac ischemia-reperfusion injury.American journal of physiology. Heart and circulatory physiology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The majority of hypoxic cells in squamous cell carcinomas of the head and neck and cervix express involucrin, a molecular marker for differentiation. This raises the question of whether involucrin is an oxygen-regulated protein and, if so, whether it could serve as an endogenous marker for tumour hypoxia. Consistent with oxygen regulation, involucrin protein was found to increase with increasing hypoxia in confluent cultures of moderately differentiated human SCC9 cells. Cells harvested at the point of confluence and exposed to graded concentrations of oxygen revealed a K(m) of approximately 15 mmHg for involucrin induction. This is similar to K(m)s for HIF-1alpha, CAIX and VEGF. Involucrin induction showed a steep dependence on pO(2) with a transition from minimum to maximum expression occurring over less than an order of magnitude change in pO(2). In contrast to SCC9 cells, involucrin was not induced by hypoxia in poorly differentiated SCC4 cells. It is concluded that involucrin is an oxygen-regulated protein, but that differentiation modulates its transcription status with respect to hypoxia induction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.