Trial reportThorax2004
Bone mineral density in Australian children, adolescents and adults with cystic fibrosis: a controlled cross sectional study.
Trial report in Thorax, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 5 syntheses or guidelines pooled it, 157 citations in OpenAlex.
- The 2025 European Cystic Fibrosis Society position statement on physical activity assessment in cystic fibrosis.European respiratory review : an official journal of the European Respiratory Society · 2025Guideline
- Vitamin D deficiency in patients with cystic fibrosis: a systematic review and meta-analysis.Journal of health, population, and nutrition · 2024Pooled it
- Bisphosphonates for osteoporosis in people with cystic fibrosis.The Cochrane database of systematic reviews · 2023Pooled it
- Interventions for promoting participation in shared decision-making for children and adolescents with cystic fibrosis.The Cochrane database of systematic reviews · 2019Pooled it
- Bisphosphonates for osteoporosis in people with cystic fibrosis.The Cochrane database of systematic reviews · 2014Pooled it
- Trial
- Chronological Age Distribution Across Risser+ Stages: A Retrospective Study of 535 Radiographs.Orthopedic reviews · 2026Article
- Prevalence of Scoliosis in Children and Adolescents with Cystic Fibrosis.Children (Basel, Switzerland) · 2024Article
- Hand grip strength, vitamin D status, and diets as predictors of bone health in 6-12 years old school children.BMC musculoskeletal disorders · 2023Observational
- Nutritional Care in Children with Cystic Fibrosis.Nutrients · 2023Review
- Physical activity and its correlates in people with cystic fibrosis: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Comparison of Physical Activity and Sedentary Behaviour between Schoolchildren with Cystic Fibrosis and Healthy Controls: A Gender Analysis.International journal of environmental research and public health · 2021Article
- Hand grip strength and maximum peak expiratory flow: determinants of bone mineral density of adolescent students.BMC pediatrics · 2018Article
- Physiotherapy for cystic fibrosis in Australia and New Zealand: A clinical practice guideline.Respirology (Carlton, Vic.) · 2016Article
- The role of daily physical activity and nutritional status on bone turnover in cystic fibrosis: a cross-sectional study.Brazilian journal of physical therapy · 2016Article
- Scoliosis Surgery in Cystic Fibrosis: Surgical Considerations and the Multidisciplinary Approach of a Rare Case.Case reports in orthopedics · 2016Article
- Peripheral quantitative computed tomography (pQCT) reveals low bone mineral density in adolescents with motor difficulties.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Article
- Factors associated with low bone mineral density in patients with cystic fibrosis.Journal of bone and mineral metabolism · 2015Article
- The effect of whole body vibration exposure on muscle function in children with cystic fibrosis: a pilot efficacy trial.Journal of clinical medicine research · 2013Article
- Lactose malabsorption is a risk factor for decreased bone mineral density in pancreatic insufficient cystic fibrosis patients.European journal of human genetics : EJHG · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow bone mineral density (BMD) is recognised in individuals with cystic fibrosis (CF) although the pathogenesis remains unclear. The aims of this study were to compare BMD over a broad continuum of Australian individuals with CF with healthy controls and to examine the relationship between BMD and clinical parameters including physical activity, nutrition, and vitamin D levels.
methodsBMD of the lumbar spine (LS), total body (TB), femoral neck (FN), cortical wrist (R33%), and distal wrist (RUD) was examined in 153 individuals with CF aged 5.3-55.8 years (84 males) and in 149 local controls aged 5.6-48.3 years (66 males) using dual energy x ray absorptiometry. Anthropometric variables, body cell mass, markers of disease severity, corticosteroid usage, measures of physical activity, dietary calcium and caloric intake and serum vitamin D were assessed and related to BMD.
resultsCompared with controls, mean BMD was not significantly different in children aged 5-10 years with CF. Adolescents (females 11-18 years, males 11-20 years) had reduced TB and R33% BMD when adjusted for age, sex, and height (difference in BMD (g/cm2) adjusted means between control and CF: TB=0.04 (95% CI 0.01 to 0.07); R33%=0.03 (95% CI 0.01 to 0.06)). BMD was reduced at all sites except R33% in adults (difference in BMD (g/cm2) adjusted means between control and CF: TB=0.05 (95% CI 0.02 to 0.09); LS=0.08 (95% CI 0.03 to 0.14); FN=0.09 (95% CI 0.03 to 0.15); RUD=0.03 (95% CI 0.01 to 0.05)). In children/adolescents BMD was weakly associated with nutritional status and disease severity.
conclusionsBMD was normal in a well nourished group of prepubertal children with CF. A BMD deficit appears to evolve during adolescence and becomes more marked in adults. Individuals with CF should optimise nutrition, partake in physical activity, and maximise lung health in order to optimise BMD. Further longitudinal studies are required to understand the evolution of reduced BMD in young people and adults with CF.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.