ArticleThorax2004
Rapid and efficient clearance of airway tissue granulocytes through transepithelial migration.
Article in Thorax, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Early phase resolution of mucosal eosinophilic inflammation in allergic rhinitis.Respiratory research · 2010Trial
- Obesity-driven airway eosinophilia and neutrophilia in asthma.The Journal of asthma : official journal of the Association for the Care of Asthma · 2025Review
- Spatial Eosinophil Phenotypes as Immunopathogenic Determinants in Inflammatory Diseases.Cells · 2025Review
- The epithelial barrier theory: Development and exacerbation of allergic and other chronic inflammatory diseases.Asia Pacific allergy · 2023Review
- The External Exposome and Allergies: From the Perspective of the Epithelial Barrier Hypothesis.Frontiers in allergy · 2022Review
- Eosinophils in the gastrointestinal tract and their role in the pathogenesis of major colorectal disorders.World journal of gastroenterology · 2019Review
- Broad Th2 neutralization and anti-inflammatory action of pentosan polysulfate sodium in experimental allergic rhinitis.Immunity, inflammation and disease · 2017Article
- Are healthy smokers really healthy?Tobacco induced diseases · 2016Review
- Pathogenesis of eosinophilic chronic rhinosinusitis.Journal of inflammation (London, England) · 2016Review
- Bronchoalveolar lavage total cell count in interstitial lung diseases--does it matter?Inflammation · 2012Article
- Resolution of leucocyte-mediated mucosal diseases. A novel in vivo paradigm for drug development.British journal of pharmacology · 2012Review
- Resolution of cell-mediated airways diseases.Respiratory research · 2010Review
- Maintained smoking cessation for 6 months equilibrates the percentage of sputum CD8+ lymphocyte cells with that of nonsmokers.Mediators of inflammation · 2009Article
- Remodeling of extra-bronchial lung vasculature following allergic airway inflammation.Respiratory research · 2008Article
- Polarized localization of epithelial CXCL11 in chronic obstructive pulmonary disease and mechanisms of T cell egression.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Epithelial Rho GTPases and the transepithelial migration of lymphocytes.Methods in enzymology · 2008Article
- Effects of steroid treatment on lung CC chemokines, apoptosis and transepithelial cell clearance during development and resolution of allergic airway inflammation.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2006Article
- Airway immunopathology of asthma with exercise-induced bronchoconstriction.The Journal of allergy and clinical immunology · 2005Article
- Anti-Fas mAb-induced apoptosis and cytolysis of airway tissue eosinophils aggravates rather than resolves established inflammation.Respiratory research · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClearance of tissue granulocytes is central to the resolution of airway inflammation. To date the focus has been on apoptotic mechanisms of cell removal and little attention has been given to alternative processes. The present study explores transepithelial migration as a mechanism of cell clearance.
methodGuinea pig tracheobronchial airways where eosinophils are constitutively present in the mucosal tissue were studied. A complex topical stimulus (allergen challenge) was applied and the fate of the eosinophils was determined by selective tracheobronchial lavage and histological examination of the tissue.
resultsWithin 10 minutes of the allergen challenge, massive migration of eosinophils into the airway lumen occurred together with a reduction in tissue eosinophil numbers. Cell clearance into the lumen continued at high speed and by 30 and 60 minutes the tissue eosinophilia had been reduced by 63% and 73%, respectively. The marked transepithelial migration (estimated maximal speed 35,000 cells/min x cm2 mucosal surface) took place ubiquitously between epithelial cells without affecting epithelial integrity as assessed by transmission and scanning electron microscopy. Eosinophil apoptosis was not detected but occasional cytolytic eosinophils occurred.
conclusionThis study shows that luminal entry has a remarkably high capacity as a granulocyte elimination process. The data also suggest that an appropriate stimulus of transepithelial migration may be used therapeutically to increase the resolution of inflammatory conditions of airway tissues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.