ArticleThorax2004
Increase in urinary leukotriene LTE4 levels in acute asthma: correlation with airflow limitation.
Article in Thorax, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 89 citations in OpenAlex.
- Biological effects of leukotriene E4 on eosinophils.Prostaglandins, leukotrienes, and essential fatty acids · 2014Trial
- A randomized, double-blind, placebo-controlled trial of oral montelukast in acute asthma exacerbation.BMC pulmonary medicine · 2013Trial
- Levels of prostaglandin E metabolite and leukotriene E(4) are increased in the urine of smokers: evidence that celecoxib shunts arachidonic acid into the 5-lipoxygenase pathway.Cancer prevention research (Philadelphia, Pa.) · 2009Trial
- Trial
- Noninvasive urinary biomarkers 3-bromotyrosine and leukotriene E4 in assessing asthma control and flare-up in children: a case-control study.European journal of pediatrics · 2026Article
- Urinary thromboxane and isoprostane levels are elevated in symptom-high T2-biomarker-low severe asthma.ERJ open research · 2025Article
- Cysteinyl Leukotrienes in Allergic Inflammation.Annual review of pathology · 2025Review
- Association of ambient air pollution and pesticide mixtures on respiratory inflammatory markers in agricultural communities.Environmental research, health : ERH · 2024Article
- Urinary eicosanoid levels in early life and risk of atopic disease in childhood.The Journal of allergy and clinical immunology · 2024Article
- In silico analysis of single nucleotide polymorphism (rs34377097) of TBXA2R gene and pollen induced bronchial asthma susceptibility in West Bengal population, India.Frontiers in immunology · 2023Article
- Pilot Study of Peak Plasma Concentration After High-Dose Oral Montelukast in Children With Acute Asthma Exacerbations.Journal of clinical pharmacology · 2021Observational
- Persistent Eosinophilic Inflammation in Adult Asthmatics with High Serum and Urine Levels of Leukotriene EJournal of asthma and allergy · 2021Article
- Association of Organophosphate Pesticide Exposure and a Marker of Asthma Morbidity in an Agricultural Community.Journal of agromedicine · 2020Article
- Characterizing the joint effects of pesticide exposure and criteria ambient air pollutants on pediatric asthma morbidity in an agricultural community.Environmental epidemiology (Philadelphia, Pa.) · 2019Article
- The mercapturomic profile of health and non-communicable diseases.High-throughput · 2019Review
- Unique Lipid Signatures of Extracellular Vesicles from the Airways of Asthmatics.Scientific reports · 2018Article
- Relationship Between Gender and the Effectiveness of Montelukast: An Italian/Danish Register-Based Retrospective Cohort Study.Frontiers in pharmacology · 2018Article
- Adverse events are rare after single-dose montelukast exposures in children.Clinical toxicology (Philadelphia, Pa.) · 2018Article
- Plasma LTE4/PGF2α Ratio and Blood Eosinophil Count Are Increased in Elderly Asthmatics With Previous Asthma Exacerbation.Allergy, asthma & immunology research · 2017Article
- Biomarkers for the Phenotyping and Monitoring of Asthma in Children.Current treatment options in allergy · 2016Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeukotrienes play a key role in the pathophysiology of chronic asthma. Activation of leukotriene pathways is accompanied by rises in detectable urinary levels of leukotriene E4 (LTE4). The relationship between urinary LTE4 levels and factors associated with acute asthma has not been determined.
methodsAdults aged 15-54 years presenting with moderate to severe acute asthma were evaluated at emergency departments in 16 US sites. Forced expiratory volume in 1 second (FEV1) was measured during the first 60 minutes after arrival and at specified times until discharge or admission. Urine samples for measurement of LTE4 levels were obtained either on arrival at the study site and/or before discharge. Patients were seen 2 weeks later for follow up, at which time repeat FEV1 measurements and urine samples for LTE4 were obtained.
resultsOne hundred and eighty four patients were evaluated; LTE4 results from both the acute and follow up periods were available for analysis in 146. Urinary LTE4 levels were increased during asthma exacerbations compared with levels obtained 2 weeks later (geometric means 111.7 and 75.6 pg/mg creatinine, respectively, mean percentage change -32.3; 95% confidence interval (CI) for the mean percentage change -39.6 to -24.3, p<0.001). The correlation between improvement in FEV1 and decline in LTE4 over the 2 week interval was significant (p<0.001, r=0.43).
conclusionsActivation of leukotriene pathways in acute asthma is correlated with the degree of airflow obstruction, and resolution of the asthma exacerbation is associated with a reduction in leukotriene levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.