ArticleGenome biology2004
Predicting specificity in bZIP coiled-coil protein interactions.
Article in Genome biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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Who cites it
48 citing papers in PubMed.
- InsiliCoil: An Integrated Software Suite for Coiled Coil Design, Prediction, and Therapeutic Engineering.ACS synthetic biology · 2026Article
- Massively parallel measurement of protein-protein interactions by sequencing using MP3-seq.Nature chemical biology · 2024Article
- The genetic architecture of protein interaction affinity and specificity.Nature communications · 2024Article
- A multiplexed bacterial two-hybrid for rapid characterization of protein-protein interactions and iterative protein design.Nature communications · 2023Article
- Maximum likelihood reconstruction of ancestral networks by integer linear programming.Bioinformatics (Oxford, England) · 2021Article
- Selective antagonism of cJun for cancer therapy.Journal of experimental & clinical cancer research : CR · 2020Review
- Construction, comparison and evolution of networks in life sciences and other disciplines.Journal of the Royal Society, Interface · 2020Article
- A conserved leucine zipper-like motif accounts for strong tetramerization capabilities of SEPALLATA-like MADS-domain transcription factors.Journal of experimental botany · 2018Article
- CCBuilder 2.0: Powerful and accessible coiled-coil modeling.Protein science : a publication of the Protein Society · 2018Article
- AP-1 (bZIP) Transcription Factors as Potential Regulators of Metallothionein Gene Expression inFrontiers in genetics · 2018Article
- α-Helical coiled-coil peptide materials for biomedical applications.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2017Review
- Protein-protein interactions in paralogues: Electrostatics modulates specificity on a conserved steric scaffold.PloS one · 2017Article
- Deriving Heterospecific Self-Assembling Protein-Protein Interactions Using a Computational Interactome Screen.Journal of molecular biology · 2016Article
- Optogenetic Inhibitor of the Transcription Factor CREB.Chemistry & biology · 2015Article
- Protein-Protein Interactions Mediated by Helical Tertiary Structure Motifs.Journal of the American Chemical Society · 2015Article
- Learning sequence determinants of protein:protein interaction specificity with sparse graphical models.Journal of computational biology : a journal of computational molecular cell biology · 2015Article
- Article
- Data-driven prediction and design of bZIP coiled-coil interactions.PLoS computational biology · 2015Article
- A humanized leucine zipper-TRAIL hybrid induces apoptosis of tumors both in vitro and in vivo.PloS one · 2015Article
- Increasing the affinity of selective bZIP-binding peptides through surface residue redesign.Protein science : a publication of the Protein Society · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a method for predicting protein-protein interactions mediated by the coiled-coil motif. When tested on interactions between nearly all human and yeast bZIP proteins, our method identifies 70% of strong interactions while maintaining that 92% of predictions are correct. Furthermore, cross-validation testing shows that including the bZIP experimental data significantly improves performance. Our method can be used to predict bZIP interactions in other genomes and is a promising approach for predicting coiled-coil interactions more generally.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.