ArticleNucleic acids research2004
Structure of a palindromic amplicon junction implicates microhomology-mediated end joining as a mechanism of sister chromatid fusion during gene amplification.
Article in Nucleic acids research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Double-strand breaks induce inverted duplication chromosome rearrangements by a DNA polymerase δ-dependent mechanism.Nature communications · 2023Article
- Mechanisms of gene duplication and amplification.Cold Spring Harbor perspectives in biology · 2015Review
- Novel role for non-homologous end joining in the formation of double minutes in methotrexate-resistant colon cancer cells.Journal of medical genetics · 2015Article
- Formation of linear amplicons with inverted duplications in Leishmania requires the MRE11 nuclease.PLoS genetics · 2014Article
- How a replication origin and matrix attachment region accelerate gene amplification under replication stress in mammalian cells.PloS one · 2014Article
- Large inverted duplications in the human genome form via a fold-back mechanism.PLoS genetics · 2014Article
- Characterization at nucleotide resolution of the homogeneously staining region sites of insertion in two cancer cell lines.Nucleic acids research · 2013Article
- Telomere dysfunction and chromosome instability.Mutation research · 2012Review
- Comprehensive long-span paired-end-tag mapping reveals characteristic patterns of structural variations in epithelial cancer genomes.Genome research · 2011Article
- Amplification of a plasmid bearing a mammalian replication initiation region in chromosomal and extrachromosomal contexts.Nucleic acids research · 2011Article
- The terminal telomeric DNA sequence determines the mechanism of dysfunctional telomere fusion.Molecular cell · 2010Article
- Palindromic gene amplification--an evolutionarily conserved role for DNA inverted repeats in the genome.Nature reviews. Cancer · 2009Review
- A familial inverted duplication/deletion of 2p25.1-25.3 provides new clues on the genesis of inverted duplications.European journal of human genetics : EJHG · 2009Article
- Redox regulation of multidrug resistance in cancer chemotherapy: molecular mechanisms and therapeutic opportunities.Antioxidants & redox signaling · 2009Review
- Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution.Genome research · 2007Article
- High-resolution mapping identifies a commonly amplified 11q13.3 region containing multiple genes flanked by segmental duplications.Human genetics · 2007Article
- The Chinese hamster dihydrofolate reductase replication origin decision point follows activation of transcription and suppresses initiation of replication within transcription units.Molecular and cellular biology · 2006Article
- Telomerase- and recombination-independent immortalization of budding yeast.Genes & development · 2004Article
- Molecular structure of double-minute chromosomes bearing amplified copies of the epidermal growth factor receptor gene in gliomas.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
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Authors and funding
3 authors.
Funding
Abstract
Amplification of the copy number of oncogenes is frequently associated with tumor progression. Often, the amplified DNA consists of large (tens to hundreds of kilobases) 'head-to-head' inverted repeat palindromes (amplicons). Several mechanisms have been proposed to explain palindrome formation but their relative contributions in nature have been difficult to assess without precise knowledge of the sequences involved at the junction of natural amplicons. Here, we have sequenced one such junction and compared this sequence to the un-rearranged structure, allowing us to pinpoint the site of sister chromatid fusion. Our results support a novel model, consistent with all described sister chromatid fusions, in which sister chromatid fusion is initiated by microhomology-mediated end joining of double strand breaks.
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