ArticleThe Journal of experimental medicine2004
GATA-3 in human T cell helper type 2 development.
Article in The Journal of experimental medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 95 citations in OpenAlex.
- Glucocorticoid receptor inhibits Th2 immune responses by down-regulating Pparg and Gata3 in schistosomiasis.Frontiers in immunology · 2025Article
- Nuclear receptor Nr1d1 alleviates asthma by abating GATA3 gene expression and Th2 cell differentiation.Cellular and molecular life sciences : CMLS · 2022Article
- Th2 cells lacking T-bet suppress naive and memory T cell responses via IL-10.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- CD4 T Helper Cell Subsets and Related Human Immunological Disorders.International journal of molecular sciences · 2020Review
- Association of Maternal Regulatory Single Nucleotide Polymorphic CD99 Genotype with Preeclampsia in Pregnancies Carrying Male Fetuses in Ethiopian Women.International journal of molecular sciences · 2020Article
- Chinese Herbal Formula, Huayu Tongbi Fang, Attenuates Inflammatory Proliferation of Rat Synoviocytes Induced by IL-1Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Juvenile idiopathic arthritis associated with a mutation in GATA3.Arthritis research & therapy · 2019Article
- Alkali-soluble pectin suppresses IgE production in human myeloma cell line in vitro.Cytotechnology · 2019Article
- Review: Transcriptional Regulation of CD4+ T Cell Differentiation in Experimentally Induced Arthritis and Rheumatoid Arthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2018Review
- Transcription regulatory factor expression in T-helper cell differentiation pathway in eutopic endometrial tissue samples of women with endometriosis associated with infertility.Central-European journal of immunology · 2018Article
- GATA3 haploinsufficiency does not block allergic sensitization or atopic disease.The Journal of allergy and clinical immunology · 2016Article
- [Effector T cells].Zeitschrift fur Rheumatologie · 2015Review
- Association of the IL4R single-nucleotide polymorphism I50V with recurrent spontaneous abortion (RSA).Journal of assisted reproduction and genetics · 2014Article
- Transcriptional regulatory networks for CD4 T cell differentiation.Current topics in microbiology and immunology · 2014Review
- Characterization of the DNA copy-number genome in the blood of cutaneous T-cell lymphoma patients.The Journal of investigative dermatology · 2012Article
- Hierarchical IL-5 expression defines a subpopulation of highly differentiated human Th2 cells.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Novel dominant-negative mutant of GATA3 in HDR syndrome.Journal of molecular medicine (Berlin, Germany) · 2011Article
- Transgenic modelling of cytokine polarization in the lung.Immunology · 2011Review
- From the cradle to the grave: activities of GATA-3 throughout T-cell development and differentiation.Immunological reviews · 2010Review
- TCR-dependent translational control of GATA-3 enhances Th2 differentiation.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The delineation of the in vivo role of GATA-3 in human T cell differentiation is a critical step in the understanding of molecular mechanisms directing human immune responses. We examined T cell differentiation and T cell-mediated effector functions in individuals lacking one functional GATA-3 allele. CD4 T cells from GATA-3+/- individuals expressed significantly reduced levels of GATA-3, associated with markedly decreased T helper cell (Th)2 frequencies in vivo and in vitro. Moreover, Th2 cell-mediated effector functions, as assessed by serum levels of Th2-dependent immunoglobulins (Igs; IgG4, IgE), were dramatically decreased, whereas the Th1-dependent IgG1 was elevated compared with GATA-3+/+ controls. Concordant with these data, silencing of GATA-3 in GATA-3+/+ CD4 T cells with small interfering RNA significantly reduced Th2 cell differentiation. Moreover, GATA-3 mRNA levels increased under Th2-inducing conditions and decreased under Th1-inducing conditions. Taken together, the data strongly suggest that GATA-3 is an important transcription factor in regulating human Th2 cell differentiation in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.