ArticlePlant molecular biology2003
Characterization of all the subunits of replication factor C from a higher plant, rice (Oryza sativa L.), and their relation to development.
Article in Plant molecular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 30 citations in OpenAlex.
- Plant-specific and conserved mechanisms of the polymerase-associated factor 1 complex in replication stress responses.Nature plants · 2026Article
- Transcriptome and small RNA sequencings reveal the response of tobacco to aphid infestation.BMC genomics · 2025Article
- Massive detection of cryptic recessive genetic defects in dairy cattle mining millions of life histories.Genome biology · 2024Article
- Multi-trait modeling and machine learning discover new markers associated with stem traits in alfalfa.Frontiers in plant science · 2024Article
- RiceInternational journal of molecular sciences · 2020Article
- Subunit Interaction Differences Between the Replication Factor C Complexes inFrontiers in plant science · 2018Article
- Multifaceted regulation and functions of replication factor C family in human cancers.American journal of cancer research · 2018Review
- Dynamics of plant DNA replication based on PCNA visualization.Scientific reports · 2016Article
- ShRNA-mediated silencing of the RFC3 gene suppress ovarian tumor cells proliferation.International journal of clinical and experimental pathology · 2015Article
- Analysis of expression profiles of selected genes associated with the regenerative property and the receptivity to gene transfer during somatic embryogenesis in Triticum aestivum L.Molecular biology reports · 2013Article
- Regulating DNA replication in plants.Cold Spring Harbor perspectives in biology · 2012Review
- Proteome characterization of developing grains in bread wheat cultivars (Triticum aestivum L.).BMC plant biology · 2012Article
- Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation.Annals of botany · 2011Review
- RFC3 regulates cell proliferation and pathogen resistance in Arabidopsis.Plant signaling & behavior · 2010Article
- Arabidopsis reactome: a foundation knowledgebase for plant systems biology.The Plant cell · 2008Article
- Genome-wide analysis of the core DNA replication machinery in the higher plants Arabidopsis and rice.Plant physiology · 2007Article
- DNA repair in higher plants; photoreactivation is the major DNA repair pathway in non-proliferating cells while excision repair (nucleotide excision repair and base excision repair) is active in proliferating cells.Nucleic acids research · 2004Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Replication factor C (RFC), which is composed of five subunits, is an important factor involved in DNA replication and repair mechanisms. Following previous studies on the RFC3 homologue from rice (Oryza sativa L. cv. Nipponbare) (OsRFC3), we succeeded in isolating and characterizing one large and three small subunits of RFC homologues from the same rice species and termed them OsRFC1, OsRFC2, OsRFC4 and OsRFC5. The plant was found to have all RFC subunits known in yeasts, human and other eukaryotes. The open reading frames of OsRFCs encoded a predicted product of 1021 amino acid residues with a molecular mass of 110.8 kDa for OsRFC1, 339 amino acid residues with a molecular mass of 37.4 kDa for OsRFC2, 335 amino acid residues with a molecular mass of 36.8 kDa for OsRFC4, and 354 amino acid residues with a molecular mass of 40.5 kDa for OsRFC5. All the OsRFC subunits have highly conserved amino acid motifs among RFC proteins, RFC box, and an unrooted phylogenetic tree shows each OsRFC subunit belongs to each RFC subunit group. These subunits showed differences in their expression patterns among tissues. The transcripts of OsRFCs were expressed strongly in the proliferating tissue, the shoot apical meristem (SAM), and very weakly in the mature leaves which have no proliferating tissues. However, in young leaves and flag leaves, tissue-specific expression of OsRFC3 and OsRFC4 was shown. On the other hand, cell cycle arrest by cell cycle inhibitors resulted in significant differences in OsRFC expression patterns. These results suggest the functional differences of each OsRFC subunit in tissues and the plant cell cycle. The roles of these molecules in plant DNA replication and DNA repair are discussed.
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