ArticleThe Journal of clinical investigation2004
Nitrate tolerance, oxidative stress, and mitochondrial function: another worrisome chapter on the effects of organic nitrates.
Article in The Journal of clinical investigation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 62 citations in OpenAlex.
- Protein kinase G2 activation restores Wnt signaling and bone mass in glucocorticoid-induced osteoporosis in mice.JCI insight · 2024Article
- The impact of dietary nitrates and acrylamide intake on systemic redox status in healthy young adults.International journal of occupational medicine and environmental health · 2023Article
- Angina in 2022: Current Perspectives.Journal of clinical medicine · 2022Review
- Vericiguat Modulates Osteoclast Differentiation and Bone Resorption via a Balance between VASP and NF-Mediators of inflammation · 2022Article
- Rosmarinic acid ameliorates acetaminophen-induced acute liver injury in mice via RACK1/TNF-α mediated antioxidant effect.Pharmaceutical biology · 2021Article
- Nitric oxide and cyclic GMP functions in bone.Nitric oxide : biology and chemistry · 2018Review
- Effects of Military activity and habitat quality on DNA damage and oxidative stress in the largest population of the Federally threatened gopher tortoise.Ecotoxicology (London, England) · 2017Article
- The effect of PDE5 inhibitors on bone and oxidative damage in ovariectomy-induced osteoporosis.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- A Novel, Direct NO Donor Regulates Osteoblast and Osteoclast Functions and Increases Bone Mass in Ovariectomized Mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Soluble guanylate cyclase as a novel treatment target for osteoporosis.Endocrinology · 2014Article
- Effects of exercise interventions on peripheral vascular endothelial vasoreactivity in patients with heart failure with reduced ejection fraction.Heart, lung & circulation · 2013Review
- Nitroglycerine-induced nitrate tolerance compromises propofol protection of the endothelial cells against TNF-α: the role of PKC-β2 and NADPH oxidase.Oxidative medicine and cellular longevity · 2013Article
- Pro-survival effects of 17β-estradiol on osteocytes are mediated by nitric oxide/cGMP via differential actions of cGMP-dependent protein kinases I and II.The Journal of biological chemistry · 2012Article
- Caveolin as a potential drug target for cardiovascular protection.Frontiers in physiology · 2012Article
- Heme proteins mediate the conversion of nitrite to nitric oxide in the vascular wall.American journal of physiology. Heart and circulatory physiology · 2008Article
- Role of cGMP-dependent protein kinase in development of tolerance to nitroglycerine in porcine coronary arteries.British journal of pharmacology · 2008Article
- Pharmacologic modulators of soluble guanylate cyclase/cyclic guanosine monophosphate in the vascular system - from bench top to bedside.Current vascular pharmacology · 2007Review
- Targeting nitric oxide with drug therapy.Journal of clinical hypertension (Greenwich, Conn.) · 2006Review
- Inhibition of mitochondrial aldehyde dehydrogenase by nitric oxide-mediated S-nitrosylation.FEBS letters · 2005Article
- An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A shortcoming in the clinical use of organic nitrates is the development of tolerance. Recent data have suggested that the denitrification of organic nitrates is mediated by mitochondrial aldehyde dehydrogenase and that dysfunction of this enzyme is an important cause of tolerance. In this issue of the JCI, evidence in support of this hypothesis is presented in an in vivo model of nitrate tolerance (see the related article beginning on page 482).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.