ArticleOncogene2004
Generation and analysis of melanoma SAGE libraries: SAGE advice on the melanoma transcriptome.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00340522 (Childhood Cancer and Plexiform Neurofibroma Tissue Microarray for Molecular Target Screening and Clinical Drug Development), which is not on this map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Childhood Cancer and Plexiform Neurofibroma Tissue Microarray for Molecular Target Screening and Clinical Drug Development
Who cites it
26 citing papers in PubMed, 71 citations in OpenAlex.
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- Claudin-1, A Double-Edged Sword in Cancer.International journal of molecular sciences · 2020Review
- Review
- Underexpression of Specific Interferon Genes Is Associated with Poor Prognosis of Melanoma.PloS one · 2017Article
- Calpain research for drug discovery: challenges and potential.Nature reviews. Drug discovery · 2016Review
- Cell Surface CD74-MIF Interactions Drive Melanoma Survival in Response to Interferon-γ.The Journal of investigative dermatology · 2015Article
- Calpain-3 impairs cell proliferation and stimulates oxidative stress-mediated cell death in melanoma cells.PloS one · 2015Article
- Transcriptome profiling of whole blood cells identifies PLEK2 and C1QB in human melanoma.PloS one · 2011Article
- NRG1 / ERBB3 signaling in melanocyte development and melanoma: inhibition of differentiation and promotion of proliferation.Pigment cell & melanoma research · 2009Article
- Wnt5A activates the calpain-mediated cleavage of filamin A.The Journal of investigative dermatology · 2009Article
- Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Wnt5A regulates expression of tumor-associated antigens in melanoma via changes in signal transducers and activators of transcription 3 phosphorylation.Cancer research · 2008Article
- Transcription analysis in the MeLiM swine model identifies RACK1 as a potential marker of malignancy for human melanocytic proliferation.Molecular cancer · 2008Article
- Suppression subtractive hybridization profiles of radial growth phase and metastatic melanoma cell lines reveal novel potential targets.BMC cancer · 2008Article
- Effect of active smoking on the human bronchial epithelium transcriptome.BMC genomics · 2007Article
- Statistical analysis and significance testing of serial analysis of gene expression data using a Poisson mixture model.BMC bioinformatics · 2007Article
- Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression.PloS one · 2007Article
- Article
- The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition.The Journal of biological chemistry · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 9 institutions in 3 countries.
Funding
Abstract
In this study, we generated three SAGE libraries from melanoma tissues. Using bioinformatics tools usually applied to microarray data, we identified several genes, including novel transcripts, which are preferentially expressed in melanoma. SAGE results converged with previous microarray analysis on the importance of intracellular calcium and G-protein signaling, and the Wnt/Frizzled family. We also examined the expression of CD74, which was specifically, albeit not abundantly, expressed in the melanoma libraries using a melanoma progression tissue microarray, and demonstrate that this protein is expressed by melanoma cells but not by benign melanocytes. Many genes involved in intracellular calcium and G-protein signaling were highly expressed in melanoma, results we had observed earlier from microarray studies (Bittner et al., 2000). One of the genes most highly expressed in our melanoma SAGE libraries was a calcium-regulated gene, calpain 3 (p94). Immunohistochemical analysis demonstrated that calpain 3 moves from the nuclei of non-neoplastic cells to the cytoplasm of malignant cells, suggesting activation of this intracellular proteinase. Our SAGE results and the clinical validation data demonstrate how SAGE profiles can highlight specific links between signaling pathways as well as associations with tumor progression. This may provide insights into new genes that may be useful for the diagnosis and therapy of melanoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.