ArticleOncogene2004
Identification of genes whose expression is upregulated in lung adenocarcinoma cells in comparison with type II alveolar cells and bronchiolar epithelial cells in vivo.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
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- MT2-MMP induces proteolysis and leads to EMT in carcinomas.Oncotarget · 2016Article
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- Uncovering Driver DNA Methylation Events in Nonsmoking Early Stage Lung Adenocarcinoma.BioMed research international · 2016Article
- Identification of a multi-cancer gene expression biomarker for cancer clinical outcomes using a network-based algorithm.Scientific reports · 2015Article
- Increased MT2-MMP expression in gastric cancer patients is associated with poor prognosis.International journal of clinical and experimental pathology · 2015Article
- Lung cancer transcriptomes refined with laser capture microdissection.The American journal of pathology · 2014Article
- Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression.Genome research · 2012Article
- Identification of novel candidate oncogenes in chromosome region 17p11.2-p12 in human osteosarcoma.PloS one · 2012Article
- Article
- Squamous Cell Carcinoma - Similarities and Differences among Anatomical Sites.American journal of cancer research · 2011Article
- Gene expression-based classification of non-small cell lung carcinomas and survival prediction.PloS one · 2010Article
- Gene expression profiles of lung adenocarcinoma linked to histopathological grading and survival but not to EGF-R status: a microarray study.BMC cancer · 2010Article
- Smoking-Related Gene Expression in Laser Capture-Microdissected Human Lung.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Article
- Dopamine depletion induces distinct compensatory gene expression changes in DARPP-32 signal transduction cascades of striatonigral and striatopallidal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Differential gene expression in human conducting airway surface epithelia and submucosal glands.American journal of respiratory cell and molecular biology · 2009Article
- Cross talk between hedgehog and epithelial-mesenchymal transition pathways in gastric pit cells and in diffuse-type gastric cancers.British journal of cancer · 2009Article
- Extreme value theory in analysis of differential expression in microarrays where either only up- or down-regulated genes are relevant or expected.Genetics research · 2008Article
- Identification of tumor markers and differentiation markers for molecular diagnosis of lung adenocarcinoma.Oncogene · 2006Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To identify genes whose expression is upregulated in lung adenocarcinoma (AdC) cells in comparison with noncancerous peripheral lung epithelial cells, type II alveolar cells and bronchiolar epithelial cells, as well as AdC cells, were isolated by laser capture microdissection, and subjected to cDNA microarray analysis of 637 human cancer-related genes. Each of the component cells was obtained from several different individuals and analysed independently. As a comparison, two lung AdC cell lines and two primarily cultured normal lung epithelial cell lines were also subjected to cDNA microarray analysis. Four genes, TOP2A, MMP15, MX2 and KOC1, were commonly upregulated in microdissected AdC cells in comparison with microdissected epithelial cells. Hierarchical clustering analysis revealed that differences in gene-expression profiles were more evident between cultured and uncultured cells than between cancerous and noncancerous cells. To further identify the common molecular targets of AdC cells in vivo, quantitative real-time RT-PCR was performed against the four genes upregulated by cDNA microarray analysis. The TOP2A, MMP15, MX2 and KOC1 genes were overexpressed in 10/10 (100%), 8/10 (80%), 5/10 (50%) and 3/10 (30%) microdissected AdC cell samples, respectively, in comparison with any of nine independently microdissected noncancerous epithelial cell samples. The TOP2A gene was commonly overexpressed in lung AdC cells, as previously reported. In addition, the MMP15 and MX2 genes were identified, for the first time, as being commonly overexpressed in lung AdC cells. These results strongly indicate that the MMP15 and MX2 genes could be novel markers for molecular diagnosis and therapy of lung AdC.
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