ArticleThe Journal of physiology2004
Propagation of pacemaker activity in the guinea-pig antrum.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 65 citations in OpenAlex.
- Decoding Gastric Reflexes: The Role of Mechanosensitive Enteric Neurons in Stomach Motility.Neurogastroenterology and motility · 2025Review
- CaPhysiological reviews · 2024Review
- CaeLife · 2021Article
- Direct optogenetic stimulation of smooth muscle cells to control gastric contractility.Theranostics · 2021Article
- Spontaneous Electrical Activity and Rhythmicity in Gastrointestinal Smooth Muscles.Advances in experimental medicine and biology · 2019Review
- Problems with extracellular recording of electrical activity in gastrointestinal muscle.Nature reviews. Gastroenterology & hepatology · 2016Review
- Spontaneous Ca(2+) transients in interstitial cells of Cajal located within the deep muscular plexus of the murine small intestine.The Journal of physiology · 2016Article
- Electrophysiological and Mechanical Characteristics in Human Ileal Motility: Recordings of Slow Waves Conductions and Contractions, In vitro.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2015Article
- Effects of gap junction inhibition on contraction waves in the murine small intestine in relation to coupled oscillator theory.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- Cholinergic signalling-regulated KV7.5 currents are expressed in colonic ICC-IM but not ICC-MP.Pflugers Archiv : European journal of physiology · 2014Article
- Interstitial cells: regulators of smooth muscle function.Physiological reviews · 2014Review
- Expression and function of a T-type Ca2+ conductance in interstitial cells of Cajal of the murine small intestine.American journal of physiology. Cell physiology · 2014Article
- The origin of segmentation motor activity in the intestine.Nature communications · 2014Article
- Circumferential and functional re-entry of in vivo slow-wave activity in the porcine small intestine.Neurogastroenterology and motility · 2013Article
- Rapid high-amplitude circumferential slow wave propagation during normal gastric pacemaking and dysrhythmias.Neurogastroenterology and motility · 2012Article
- Quantification of the effects of the volume and viscosity of gastric contents on antral and fundic activity in the rat stomach maintained ex vivo.Digestive diseases and sciences · 2010Article
- Ca2+ imaging of activity in ICC-MY during local mucosal reflexes and the colonic migrating motor complex in the murine large intestine.The Journal of physiology · 2010Article
- Interstitial cells of Cajal in the cynomolgus monkey rectoanal region and their relationship to sympathetic and nitrergic nerves.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- Biomagnetic signatures of uncoupled gastric musculature.Neurogastroenterology and motility · 2009Article
- Prostaglandin regulation of gastric slow waves and peristalsis.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Cyclical periods of depolarization (slow waves) underlie peristaltic contractions involved in mixing and emptying of contents in the gastric antrum. Slow waves originate from a myenteric network of interstitial cells of Cajal (ICC-MY). In this study we have visualized the sequence and propagation of Ca(2+) transients associated with pacemaker potentials in the ICC network and longitudinal (LM) and circular muscle (CM) layers of the isolated guinea-pig gastric antrum. Gastric antrum was dissected to reveal the ICC-MY network, loaded with Fluo-4 AM and activity was monitored at 37 degrees C. Ca(2+) waves propagated throughout the ICC-MY network at an average velocity of 3.24 +/- 0.12 mm s(-1) at a frequency of 4.87 +/- 0.16 cycles min(-1) (n= 4). The propagation of the Ca(2+) wave often appeared 'step-like', with separate regions of the network being activated after variable delays. The direction of propagation was highly variable (Delta angle of propagation 44.3 +/- 10.9 deg per cycle) and was not confined to the axes of the longitudinal or circular muscle. Ca(2+) waves appeared to spread out radially from the site of initiation. The initiating Ca(2+) wave in ICC-MY was correlated to secondary Ca(2+) waves in intramuscular interstitial cells of Cajal, ICC-IM, and smooth muscle cells, and the local distortion (contraction) in a field of view. TTX (1 microm) had little effect on slow wave or pacemaker potential activity, but 2-APB (50 microm) blocked all Ca(2+) waves, indicating a pivotal role for intracellular Ca(2+) stores. Nicardipine (2 microm) eliminated the Ca(2+) transient generated by smooth muscle, but did not affect the fast upstroke associated with ICC-MY. These results indicate that slow waves follow a sequence of activation, beginning with the ICC-MY and ICC-IM network, followed later by a sustained Ca(2+) transient in the muscle layers that is responsible for contraction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.