ArticleJournal of lipid research2004
Genetic determinants of obesity-related lipid traits.
Article in Journal of lipid research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Genetic architecture of lipid traits changes over time and differs by race: Princeton Lipid Follow-up Study.Journal of lipid research · 2014Trial
- A novel method, the Variant Impact On Linkage Effect Test (VIOLET), leads to improved identification of causal variants in linkage regions.European journal of human genetics : EJHG · 2014Article
- Article
- Accounting for a quantitative trait locus for plasma triglyceride levels: utilization of variants in multiple genes.PloS one · 2012Article
- A two-step genetic study on quantitative precursors of coronary artery disease in a homogeneous Indian population: case-control association discovery and validation by transmission-disequilibrium test.Journal of biosciences · 2011Article
- Detection of quantitative trait loci affecting serum cholesterol, LDL, HDL, and triglyceride in pigs.BMC genetics · 2011Article
- Serotonin (5-HT) receptor 5A sequence variants affect human plasma triglyceride levels.Physiological genomics · 2010Article
- Univariate and bivariate linkage analysis identifies pleiotropic loci underlying lipid levels and type 2 diabetes risk.Annals of human genetics · 2010Article
- INSIG1 influences obesity-related hypertriglyceridemia in humans.Journal of lipid research · 2010Article
- Quantification of the clinical modifiers impacting high-density lipoprotein cholesterol in the community: Personalized Medicine Research Project.Preventive cardiology · 2010Article
- Genetic variation in cannabinoid receptor 1 (CNR1) is associated with derangements in lipid homeostasis, independent of body mass index.Pharmacogenomics · 2008Article
- A genome-wide linkage scan identifies multiple chromosomal regions influencing serum lipid levels in the population on the Samoan islands.Journal of lipid research · 2008Article
- Automated SNP genotype clustering algorithm to improve data completeness in high-throughput SNP genotyping datasets from custom arrays.Genomics, proteomics & bioinformatics · 2007Article
- Comparison of linkage disequilibrium patterns between the HapMap CEPH samples and a family-based cohort of Northern European descent.Genomics · 2006Article
- Genome-wide linkage analysis of population variation in high-density lipoprotein cholesterol.Human genetics · 2006Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
In our ongoing effort to identify genes influencing the biological pathways that underlie the metabolic disturbances associated with obesity, we performed genome-wide scanning in 2,209 individuals distributed over 507 Caucasian families to localize quantitative trait loci (QTLs), which affect variation of plasma lipids. Pedigree-based analysis using a quantitative trait variance component linkage method that localized a QTL on chromosome 7q35-q36, which linked to variation in levels of plasma triglyceride [TG, logarithm of odds (LOD) score = 3.7] and was suggestive of linkage to LDL-cholesterol (LDL-C, LOD = 2.2). Covariates of the TG linkage included waist circumference, fasting insulin, and insulin:glucose, but not body mass index or hip circumference. Plasma HDL-cholesterol (HDL-C) levels were suggestively linked to a second QTL on chromosome 12p12.3 (LOD = 2.6). Five other QTLs with lower LOD scores were identified for plasma levels of LDL-C, HDL-C, and total cholesterol. These newly identified loci likely harbor genetic elements that influence traits underlying lipid adversities associated with obesity.
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