ArticleEnvironmental health perspectives2004
Developmental effects of chlorpyrifos extend beyond neurotoxicity: critical periods for immediate and delayed-onset effects on cardiac and hepatic cell signaling.
Article in Environmental health perspectives, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 62 citations in OpenAlex.
- Chlorpyrifos and Chlorpyrifos-Oxon: A Widening Spectrum of Toxicity.International journal of molecular sciences · 2026Review
- Grape seed extract prevents chlorpyrifos-induced toxicity in rat liver through the modulation of phase I detoxification pathway.Environmental science and pollution research international · 2024Article
- Effect of moringa seed extract in chlorpyrifos-induced cerebral and ocular toxicity in mice.Frontiers in veterinary science · 2024Article
- Whole transcriptome analysis in offspring whose fathers were exposed to a developmental insult: a novel avian model.Scientific reports · 2023Article
- Review
- Molecular neural crest cell markers enable discrimination of organophosphates in the murine cardiac embryonic stem cell test.Toxicology reports · 2021Article
- Prenatal maternal organophosphorus pesticide exposures, paraoxonase 1, and childhood adiposity in the Mount Sinai Children's Environmental Health Study.Environment international · 2020Article
- Determination of dichlorvos residue levels in vegetables sold in Lusaka, Zambia.The Pan African medical journal · 2016Article
- Combination effects of (tri)azole fungicides on hormone production and xenobiotic metabolism in a human placental cell line.International journal of environmental research and public health · 2014Article
- In vivo antioxidative and neuroprotective effect of 4-Allyl-2-methoxyphenol against chlorpyrifos-induced neurotoxicity in rat brain.Molecular and cellular biochemistry · 2014Article
- Induction of endocannabinoid levels in juvenile rat brain following developmental chlorpyrifos exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Does thyroid disruption contribute to the developmental neurotoxicity of chlorpyrifos?Environmental toxicology and pharmacology · 2013Article
- Effect of developmental chlorpyrifos exposure, on endocannabinoid metabolizing enzymes, in the brain of juvenile rats.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
- Developmental neurotoxicity targeting hepatic and cardiac sympathetic innervation: effects of organophosphates are distinct from those of glucocorticoids.Brain research bulletin · 2011Article
- Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity?Reproductive toxicology (Elmsford, N.Y.) · 2011Review
- Organophosphate exposure during a critical developmental stage reprograms adenylyl cyclase signaling in PC12 cells.Brain research · 2010Article
- Neonatal parathion exposure and interactions with a high-fat diet in adulthood: Adenylyl cyclase-mediated cell signaling in heart, liver and cerebellum.Brain research bulletin · 2010Article
- Neonatal organophosphorus pesticide exposure alters the developmental trajectory of cell-signaling cascades controlling metabolism: differential effects of diazinon and parathion.Environmental health perspectives · 2010Article
- Neonatal exposure to parathion alters lipid metabolism in adulthood: Interactions with dietary fat intake and implications for neurodevelopmental deficits.Brain research bulletin · 2010Article
- Effect of chlorpyrifos on healing of cutaneous leishmaniasis lesions after treatment with Pentostam(®).Saudi journal of biological sciences · 2009Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The fetal and neonatal neurotoxicity of chlorpyrifos (CPF) and related insecticides is a major concern. Developmental effects of CPF involve mechanisms over and above cholinesterase inhibition, notably events in cell signaling that are shared by nonneural targets. In the present study, we evaluated the immediate and long-term effects of CPF exposure of rats during different developmental windows [gestational days (GD) 9-12 or 17-20, postnatal days (PN) 1-4 or 11-14] on the adenylyl cyclase (AC) signaling cascade in the heart and liver. In addition to basal AC activity, we assessed the responses to direct AC stimulants (forskolin, Mn2+); to isoproterenol and glucagon, which activate signaling through specific membrane receptors; and to sodium fluoride, which activates the G-proteins that couple the receptors to AC. Few immediate effects on AC were apparent when CPF doses remained below the threshold for systemic toxicity. Nevertheless, CPF exposures on GD9-12, GD17-20, or PN1-4 elicited sex-selective effects that emerged by adulthood (PN60), whereas later exposure (PN11-14) elicited smaller, nonsignificant effects, indicative of closure of the window of vulnerability. Most of the effects were heterologous, involving signaling elements downstream from the receptors, and thus were shared by multiple inputs; superimposed on this basic pattern, there were also selective alterations in receptor-mediated responses. These results suggest that the developmental toxicity of CPF extends beyond the nervous system, to include cell signaling cascades that are vital to cardiac and hepatic homeostasis. Future work needs to address the potential implications of these effects for cardiovascular and metabolic disorders that may emerge long after the end of CPF exposure.
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