Evidence map›Paper›PMID 14754509›Full record

ReviewJournal of cellular and molecular medicine

Genetic clock of biologic rhythms.

C Badiu

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. An Update on Neuroaging on Earth and in Spaceflight.International journal of molecular sciences · 2025
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Construction of a plasmid for overexpression of human circadian gene period2 and its biological activity in osteosarcoma cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
    Article
  8. Article
  9. Article
  10. Relationships between circadian rhythms and modulation of gene expression by glucocorticoids in skeletal muscle.American journal of physiology. Regulatory, integrative and comparative physiology · 2008
    Article
  11. Circadian variations in rat liver gene expression: relationships to drug actions.The Journal of pharmacology and experimental therapeutics · 2008
    Article
  12. Article
  13. Rocking around the clock, while time is relative.Journal of molecular medicine (Berlin, Germany) · 2005
    Article
  14. Tissue engineering of cultured skin substitutes.Journal of cellular and molecular medicine
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

C BadiuDepartment of Endocrinology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania. badicrin@yahoo.co.uk
Carol Davila University of Medicine and Pharmacy · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biologic rhythms are tightly regulated in all species, in order to adapt to circadian variations of light, temperature and other biological related living conditions. The intrinsic mechanisms of rhythm regulation from every cell to a whole organism is embedded into the genetic clockwork. The mammalian clock genes are reviewed with their interrelation. The per gene promoter is stimulated by clock/bmal1 heterodimer and trigger the per proteins synthesis. Initially considered as a simple negative feed-back, from to the phosphorylated per/cry heterodimer towards clock/bmal1 transcription stimulus, the clockweb of the cell became complex. General characteristics of cell clock genes are integrated in a model. In addition, the involvement of clock genes in peripheral tissues is discussed.

Indexed as

AnimalsBiological ClocksCardiovascular DiseasesCerebrovascular DisordersCircadian RhythmDigestive System Physiological PhenomenaDrug Administration ScheduleHumansLightLiverModels, BiologicalNeoplasms

Identifiers

PMID14754509
PMCPMC6740273
OpenAlexW2052128869

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.