ReviewJournal of cellular and molecular medicine
Plasticity of purine release during cerebral ischemia: clinical implications?
Review in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 55 citations in OpenAlex.
- Accelerated Extracellular Nucleotide Metabolism in Brain Microvascular Endothelial Cells in Experimental Hypercholesterolemia.Cellular and molecular neurobiology · 2023Article
- The Purine Salvage Pathway and the Restoration of Cerebral ATP: Implications for Brain Slice Physiology and Brain Injury.Neurochemical research · 2019Review
- The Purinome and the preBötzinger Complex - A Ménage of Unexplored Mechanisms That May Modulate/Shape the Hypoxic Ventilatory Response.Frontiers in cellular neuroscience · 2019Article
- The combination of ribose and adenine promotes adenosine release and attenuates the intensity and frequency of epileptiform activity in hippocampal slices: Evidence for the rapid depletion of cellular ATP during electrographic seizures.Journal of neurochemistry · 2018Article
- Blood purine measurements as a rapid real-time indicator of reversible brain ischaemia.Purinergic signalling · 2017Observational
- Enteric Glial Cells: A New Frontier in Neurogastroenterology and Clinical Target for Inflammatory Bowel Diseases.Inflammatory bowel diseases · 2016Review
- Neuroinflammation after neonatal hypoxia-ischemia is associated with alterations in the purinergic system: adenosine deaminase 1 isoenzyme is the most predominant after insult.Molecular and cellular biochemistry · 2015Article
- Brain Injury Alters Ectonucleotidase Activities and Adenine Nucleotide Levels in Rat Serum.Journal of medical biochemistry · 2015Article
- Expression of ecto-nucleoside triphosphate diphosphohydrolase1-3 (NTPDase1-3) by cortical astrocytes after exposure to pro-inflammatory factors in vitro.Journal of molecular neuroscience : MN · 2013Article
- Hypoxia-ischemia alters nucleotide and nucleoside catabolism and Na+,K+-ATPase activity in the cerebral cortex of newborn rats.Neurochemical research · 2013Article
- Measurement of purine release with microelectrode biosensors.Purinergic signalling · 2012Article
- Differential contributions of adenosine to hypoxia-evoked depressions of three neuronal pathways in isolated spinal cord of neonatal rats.British journal of pharmacology · 2011Article
- Adenosine and inosine release during hypoxia in the isolated spinal cord of neonatal rats.British journal of pharmacology · 2010Article
- Release of adenosine and ATP during ischemia and epilepsy.Current neuropharmacology · 2009Article
- Roles of purines in synaptic modulation evoked by hypercapnia in isolated spinal cord of neonatal rat in vitro.British journal of pharmacology · 2009Article
- Ischemic tolerance as an active and intrinsic neuroprotective mechanism.Handbook of clinical neurology · 2009Review
- HIF-1 alpha is an essential effector for purine nucleoside-mediated neuroprotection against hypoxia in PC12 cells and primary cerebellar granule neurons.Journal of neurochemistry · 2008Article
- The role of ATP and adenosine in the brain under normoxic and ischemic conditions.Purinergic signalling · 2007Article
- Temporal and mechanistic dissociation of ATP and adenosine release during ischaemia in the mammalian hippocampus.Journal of neurochemistry · 2007Article
- Hypoxia-induced changes in neuronal network properties.Molecular neurobiology · 2005Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adenosine is a powerful modulator of neuronal function in the mammalian central nervous system. During a variety of insults to the brain, adenosine is released in large quantities and exerts a neuroprotective influence largely via the A(1) receptor, which inhibits glutamate release and neuronal activity. Using novel enzyme-based adenosine sensors, which allow high spatial and temporal resolution recordings of adenosine release in real time, we have investigated the release of adenosine during hypoxia/ischemia in the in vitro hippocampus. Our data reveal that during the early stages of hypoxia adenosine is likely released per se and not as a precursor such as cAMP or an adenine nucleotide. In addition, repeated hypoxia results in reduced production of extracellular adenosine and this may underlie the increased vulnerability of the mammalian brain to repetitive or secondary hypoxia/ischemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.