ReviewJournal of cellular and molecular medicine
Involvement of protein kinase C-delta in DNA damage-induced apoptosis.
Review in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 102 citations in OpenAlex.
- Multiple subcellular localizations and functions of protein kinase Cδ in liver cancer.World journal of gastroenterology · 2022Review
- A cancer-associated, genome protective programme engaging PKCε.Advances in biological regulation · 2020Review
- The pro-apoptotic actions of 2-methoxyestradiol against ovarian cancer involve catalytic activation of PKCδ signaling.Oncotarget · 2020Article
- Determination of the Role and Active Sites of PKC-Delta-Like from Lamprey in Innate Immunity.International journal of molecular sciences · 2019Article
- PLOD3 suppression exerts an anti-tumor effect on human lung cancer cells by modulating the PKC-delta signaling pathway.Cell death & disease · 2019Article
- Protein Kinase CJournal of the American Society of Nephrology : JASN · 2017Article
- α-Tocopherol at Nanomolar Concentration Protects Cortical Neurons against Oxidative Stress.International journal of molecular sciences · 2017Article
- Article
- PKCδ maintains phenotypes of tumor initiating cells through cytokine-mediated autocrine loop with positive feedback.Oncogene · 2015Article
- Potentially Beneficial Effect of Hydroxychloroquine in a Patient with a Novel Mutation in Protein Kinase Cδ Deficiency.Journal of clinical immunology · 2015Article
- Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkcδ.PLoS pathogens · 2014Article
- Rottlerin-induced autophagy leads to the apoptosis in breast cancer stem cells: molecular mechanisms.Molecular cancer · 2013Article
- Isozyme-specific interaction of protein kinase Cδ with mitochondria dissected using live cell fluorescence imaging.The Journal of biological chemistry · 2012Article
- Statin-dependent activation of protein kinase Cδ in acute promyelocytic leukemia cells and induction of leukemic cell differentiation.Leukemia & lymphoma · 2012Article
- Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer.The Journal of clinical investigation · 2011Article
- PKCδ-dependent signaling mediates ethambutol-induced toxic effects on human retinal pigment cells.Molecular vision · 2011Article
- Gene expression profiling in rodent models for schizophrenia.Current neuropharmacology · 2010Article
- Regulation of HuR by DNA Damage Response Kinases.Journal of nucleic acids · 2010Article
- Role for PKC δ in Fenretinide-Mediated Apoptosis in Lymphoid Leukemia Cells.Journal of signal transduction · 2010Article
- Protein kinase C delta-mediated processes in cholecystokinin-8-stimulated pancreatic acini.Pancreas · 2009Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Apoptosis is a highly orchestrated cell suicidal program required to maintain a balance between cell proliferation and cell death. A defect in apoptotic machinery can cause cancer. Many anticancer drugs are known to kill tumor cells by inducing apoptosis, and a defect in apoptosis can lead to anticancer drug resistance. Apoptosis is regulated by a complex cellular signaling network. Several members of the protein kinase C (PKC) family serve as substrates for caspases and PKCdelta isozyme has been intimately associated with DNA damage-induced apoptosis. It can act both upstream and downstream of caspases. In response to apoptotic stimuli, the full-length and the catalytic fragment of PKCdelta may translocate to distinct cellular compartments, including mitochondria and the nucleus, to reach their targets. Both activation and intracellular distribution of PKCdelta may have significant impact on apoptosis. This review intends to assimilate recent views regarding the involvement of PKCdelta in DNA damage-induced apoptosis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.