ArticleNucleic acids research2004
Characterization of the 5'-untranslated region of YB-1 mRNA and autoregulation of translation by YB-1 protein.
Article in Nucleic acids research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Y-box binding protein 1/cyclin A1 axis specifically promotes cell cycle progression at GScientific reports · 2024Article
- Towards the mechanism(s) of YB-3 synthesis regulation by YB-1.RNA biology · 2021Article
- Y-box binding protein YBX1 and its correlated genes as biomarkers for poor outcomes in patients with breast cancer.Oncotarget · 2018Article
- Ancient and modern: hints of a core post-transcriptional network driving chemotherapy resistance in ovarian cancer.Wiley interdisciplinary reviews. RNA · 2018Review
- Cold Shock Proteins Mediate GN with Mesangioproliferation.Journal of the American Society of Nephrology : JASN · 2016Article
- YB-1 transforms human mammary epithelial cells through chromatin remodeling leading to the development of basal-like breast cancer.Stem cells (Dayton, Ohio) · 2014Article
- A murine retrovirus co-Opts YB-1, a translational regulator and stress granule-associated protein, to facilitate virus assembly.Journal of virology · 2014Article
- Alternative forms of Y-box binding protein 1 and YB-1 mRNA.PloS one · 2014Article
- Article
- YB-1 binds to CAUC motifs and stimulates exon inclusion by enhancing the recruitment of U2AF to weak polypyrimidine tracts.Nucleic acids research · 2012Article
- Unraveling regulation and new components of human P-bodies through a protein interaction framework and experimental validation.RNA (New York, N.Y.) · 2011Article
- YBX1 expression and function in early hematopoiesis and leukemic cells.Immunogenetics · 2011Article
- A conserved stem loop motif in the 5'untranslated region regulates transforming growth factor-β(1) translation.PloS one · 2010Article
- Y-box binding protein-1 is a novel molecular target for tumor vessels.Cancer science · 2010Article
- Article
- A role for hnRNP C1/C2 and Unr in internal initiation of translation during mitosis.The EMBO journal · 2007Article
- Translation initiation factor 4E inhibits differentiation of erythroid progenitors.Molecular and cellular biology · 2005Article
- Significance of the Y-box proteins in human cancers.Journal of molecular and genetic medicine : an international journal of biomedical research · 2005Article
- The fragile X mental retardation protein has nucleic acid chaperone properties.Nucleic acids research · 2004Article
- Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The eukaryotic Y-box binding protein YB-1 is involved in various biological processes, including DNA repair, cell proliferation and the regulation of transcription and translation. YB-1 protein is abundant and expressed ubiquitously in human cells, functioning in cell proliferation and transformation. Its concentration is thought to be highly regulated at both the levels of transcription and translation. Therefore, we investigated whether or not the 5'-UTR of YB-1 mRNA affects the translation of YB-1 protein, thus influencing expression levels. Luciferase mRNA ligated to the YB-1 mRNA 5'-UTR was used as a reporter construct. Ligation of the full-length YB-1 5'-UTR (331 bases) enhanced translation as assessed by in vitro and in vivo translation assays. Deletion constructs of the YB-1 5'-UTR also resulted in a higher efficiency of translation, especially in the region mapped to +197 to +331 from the major transcription start site. RNA gel shift assays revealed that the affinity of YB-1 for various 5'-UTR probe sequences was higher for the full-length 5'-UTR than for deleted 5'-UTR sequences. An in vitro translation assay was used to demonstrate that recombinant YB-1 protein inhibited translation of the full-length 5'-UTR of YB-1 mRNA. Thus, our findings provide evidence for the autoregulation of YB-1 mRNA translation via the 5'-UTR.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.