ArticleNucleic acids research1992
Organization of the unr/N-ras locus: characterization of the promoter region of the human unr gene.
Article in Nucleic acids research, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 11 citations in OpenAlex.
- CSDE1 depletion inhibits tumor progression through enhancing B-cell infiltration in NSCLC.Cell death & disease · 2025Article
- Pleiotropic roles of cold shock proteins with special emphasis on unexplored cold shock protein member of Plasmodium falciparum.Malaria journal · 2020Review
- The role of CSDE1 in translational reprogramming and human diseases.Cell communication and signaling : CCS · 2020Review
- Cold shock proteins: from cellular mechanisms to pathophysiology and disease.Cell communication and signaling : CCS · 2018Review
- Murine leukemia virus proviral insertions between the N-ras and unr genes in B-cell lymphoma DNA affect the expression of N-ras only.Journal of virology · 2001Article
- Nucleic acid binding and intracellular localization of unr, a protein with five cold shock domains.Nucleic acids research · 1994Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Investigations of the structure and expression of the N-ras gene in mammals has led to the identification of another gene designated unr, which is located immediately upstream of N-ras. These two genes are transcribed in the same orientation and the intergenic distance is of the order of 150 nucleotides. This genetic organization has been observed in the genome of guinea pig, rat, mouse and man with a very high level of sequence conservation in the intergenic region. This unusual gene clustering suggests that the transcriptional regulation of this locus could involve common regulatory sequences as well as transcriptional interference between the two genes. In this study, we have isolated and characterized the human unr promoter. A cluster of transcription initiation sites was mapped by primer extension and RNase protection and shown to be located in a CpG island devoid of TATA and CAAT boxes. Functional organization of the promoter was investigated by measuring the ability of a set of 5' deletions within a1 kb promoter region to drive the expression of the luciferase gene. These studies indicated a very strong promoter activity in NIH 3T3 cells and the presence of positive and negative regulatory domains. Nevertheless, a 90 bp fragment showed the same level of promoter activity as the 1 kb fragment. We also showed that ras genes can transactivate the unr promoter activity and that the 90 bp fragment responded to this transactivation.
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