ArticleNucleic acids research1992
The yeast nuclear gene MRF1 encodes a mitochondrial peptide chain release factor and cures several mitochondrial RNA splicing defects.
Article in Nucleic acids research, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Translation in Mitochondrial Ribosomes.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Cultured bloodstream Trypanosoma brucei adapt to life without mitochondrial translation release factor 1.Scientific reports · 2018Article
- Ribosome recycling defects modify the balance between the synthesis and assembly of specific subunits of the oxidative phosphorylation complexes in yeast mitochondria.Nucleic acids research · 2016Article
- Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria.RNA (New York, N.Y.) · 2010Article
- Mitochondrial release factor in yeast: interplay of functional domains.Current genetics · 2008Article
- Article
- mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG.Molecular cell · 2007Article
- Chloroplast ribosome release factor 1 (AtcpRF1) is essential for chloroplast development.Plant molecular biology · 2007Article
- Expression of mitochondrial release factor in relation to respiratory competence in yeast.Current genetics · 2005Article
- Temperature-sensitive mutation in yeast mitochondrial ribosome recycling factor (RRF).Nucleic acids research · 2003Article
- Evolutionary conservation of reactions in translation.Microbiology and molecular biology reviews : MMBR · 2002Review
- Metabolic control analysis of the bc1 complex of Saccharomyces cerevisiae: effect on cytochrome c oxidase, respiration and growth rate.The Biochemical journal · 1998Article
- Overexpression of human release factor 1 alone has an antisuppressor effect in human cells.Molecular and cellular biology · 1997Article
- The translational function of nucleotide C1054 in the small subunit rRNA is conserved throughout evolution: genetic evidence in yeast.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- The products of the SUP45 (eRF1) and SUP35 genes interact to mediate translation termination in Saccharomyces cerevisiae.The EMBO journal · 1995Article
- Identification of cutC and cutF (nlpE) genes involved in copper tolerance in Escherichia coli.Journal of bacteriology · 1995Article
- Effect of mutations in genes affecting homologous recombination on restriction enzyme-mediated and illegitimate recombination in Saccharomyces cerevisiae.Molecular and cellular biology · 1994Article
- Polypeptide chain termination in Saccharomyces cerevisiae.Current genetics · 1994Review
- Termination of protein synthesis.Molecular biology reports · 1994Review
- Protein synthesis in mitochondria.Molecular biology reports · 1994Review
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
We report the molecular cloning, sequencing and genetic characterization of the first gene encoding an organellar polypeptide chain release factor, the MRF1 gene of the yeast Saccharomyces cerevisiae. The MRF1 gene was cloned by genetic complementation of a respiratory deficient mutant disturbed in the expression of the mitochondrial genes encoding cytochrome c oxidase subunit 1 and 2, COX1 and COX2. For COX1 this defect has been attributed to an impaired processing of several introns. Sequence analysis of the MRF1 gene revealed that it encodes a protein highly similar to prokaryotic peptide chain release factors, especially RF-1. Disruption of the gene results in a high instability of the mitochondrial genome, a hallmark for a strict lesion in mitochondrial protein synthesis. The respiratory negative phenotype of mrf1 mutants lacking all known mitochondrial introns and the reduced synthesis of mitochondrial translation products encoded by unsplit genes confirm a primary defect in mitochondrial protein synthesis. Over-expression of the MRF1 gene in a mitochondrial nonsense suppressor strain reduces suppression in a dosage-dependent manner, shedding new light on the role of the '530 region' of 16S-like ribosomal RNA in translational fidelity.
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