ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2004
The M2 muscarinic receptor mediates in vitro bladder contractions from patients with neurogenic bladder dysfunction.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 105 citations in OpenAlex.
- PIEZO1-mediated mechanosensation links aging to bladder dysfunction.bioRxiv : the preprint server for biology · 2026Article
- Overactive Bladder Symptoms Within Nervous System: A Focus on Etiology.Frontiers in physiology · 2021Review
- Effect of amniotic fluid stem cell transplantation on the recovery of bladder dysfunction in spinal cord-injured rats.Scientific reports · 2020Article
- The role of the mucosa in modulation of evoked responses in the spinal cord injured rat bladder.Neurourology and urodynamics · 2018Article
- Evaluation of the incidence and risk factors associated with persistent frequency in interstitial cystitis/bladder pain syndrome and the efficacy of antimuscarinic treatment.Investigative and clinical urology · 2017Article
- Impaired contraction and decreased detrusor innervation in a female rat model of pelvic neuropraxia.International urogynecology journal · 2017Article
- Big-conductance CaChannels (Austin, Tex.) · 2016Review
- Contractile effects and receptor analysis of adenosine-receptors in human detrusor muscle from stable and neuropathic bladders.Naunyn-Schmiedeberg's archives of pharmacology · 2016Article
- Medical management of neurogenic bladder with oral therapy.Translational andrology and urology · 2016Review
- Research Findings on Overactive Bladder.Current urology · 2015Review
- Urinary Retention, Incontinence, and Dysregulation of Muscarinic Receptors in Male Mice Lacking Mras.PloS one · 2015Article
- Functional and molecular changes of the bladder in rats with crushing injury of nerve bundles from major pelvic ganglion to the bladder: role of RhoA/Rho kinase pathway.International journal of molecular sciences · 2013Article
- Activation of muscarinic M3 receptors inhibits large-conductance voltage- and Ca2+-activated K+ channels in rat urinary bladder smooth muscle cells.American journal of physiology. Cell physiology · 2013Article
- The impact of discrete modes of spinal cord injury on bladder muscle contractility.BMC urology · 2013Article
- The effect of hypercholesterolemia on carbachol-induced contractions of the detrusor smooth muscle in rats: increased role of L-type Ca2+ channels.Naunyn-Schmiedeberg's archives of pharmacology · 2012Article
- Individual receptor profiling as a novel tool to support diagnosis of bladder pain syndrome/interstitial cystitis (BPS/IC).World journal of urology · 2012Article
- Survey of spinal cord injury-induced neurogenic bladder studies using the Web of Science.Neural regeneration research · 2012Article
- Management of urinary incontinence.P & T : a peer-reviewed journal for formulary management · 2012Article
- Impaired M3 and enhanced M2 muscarinic receptor contractile function in a streptozotocin model of mouse diabetic urinary bladder.Naunyn-Schmiedeberg's archives of pharmacology · 2010Article
- In vivo and in vitro pharmacological characterization of SVT-40776, a novel M3 muscarinic receptor antagonist, for the treatment of overactive bladder.British journal of pharmacology · 2009Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Bladder muscle specimens from seven patients with neurogenic bladder dysfunction were analyzed to determine whether the muscarinic receptor subtype mediating contraction shifts from M(3) to the M(2) subtype as found in the denervated, hypertrophied rat bladder. Seven bladder specimens were analyzed from six female and one male patients. Six of the patients had traumatic cervical spinal cord injuries (C(4)-C(7)), and the other patient had an L(1) congenital myelomeningocele. This was compared with results from bladder specimens obtained from eight organ transplant donors. The affinities of three subtype-selective muscarinic receptor antagonists for inhibition of carbachol-induced contractions were determined. The affinity of the M(3) selective antagonists darifenacin or p-fluoro-hexahydrosiladifenadol (p-F-HHSiD) was determined in six of the seven spinal injury patient specimens. The affinity was consistent with M(2)-mediated contractions in four of these six specimens, intermediate between M(2) and M(3) in one specimen, and within the M(3) range in one specimen. The other specimen, tested only with the M(2) selective antagonist methoctramine, showed an M(3) affinity. In the organ donors, the affinity of p-F-HHSiD was within the M(2) range for six of seven specimens, whereas the affinity of darifenacin was within the M(3) range for five of six and intermediate between M(2) and M(3) for the other specimen tested. The affinity of methoctramine in both organ donor specimens tested was within the M(3) range. Whereas normal detrusor contractions are mediated by the M(3) receptor subtype, in patients with neurogenic bladder dysfunction as well as certain organ transplant donors, contractions can be mediated by the M(2) muscarinic receptor subtype.
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