ArticleNucleic acids research1992
Transcriptional regulation by folate: inducible gene expression in Dictyostelium transformants during growth and early development.
Article in Nucleic acids research, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 65 citations in OpenAlex.
- Article
- De novo actin polymerization is required for model Hirano body formation in Dictyostelium.Biology open · 2016Article
- Requirements for Hirano body formation.Eukaryotic cell · 2014Article
- Autophagy contributes to degradation of Hirano bodies.Autophagy · 2009Article
- RacB regulates cytoskeletal function in Dictyostelium spp.Eukaryotic cell · 2003Article
- RNAi in Dictyostelium: the role of RNA-directed RNA polymerases and double-stranded RNase.Molecular biology of the cell · 2002Article
- Inducible expression of exogenous genes in Dictyostelium discoideum using the ribonucleotide reductase promoter.Nucleic acids research · 2001Article
- gdt1, a new signal transduction component for negative regulation of the growth-differentiation transition in Dictyostelium discoideum.Molecular biology of the cell · 2000Article
- Dynein intermediate chain mediated dynein-dynactin interaction is required for interphase microtubule organization and centrosome replication and separation in Dictyostelium.The Journal of cell biology · 1999Article
- Overexpression of an activated rasG gene during growth blocks the initiation of Dictyostelium development.Molecular and cellular biology · 1996Article
- Multiple roles of the novel protein tyrosine phosphatase PTP3 during Dictyostelium growth and development.Molecular and cellular biology · 1996Article
- Antagonistic effects of signal transduction by intracellular and extracellular cAMP on gene regulation in Dictyostelium.Molecular biology of the cell · 1996Article
- Analysis of gene function in Dictyostelium.Experientia · 1995Review
- PSF and CMF, autocrine factors that regulate gene expression during growth and early development of Dictyostelium.Experientia · 1995Review
- Overexpression of myosin motor domains in Dictyostelium: screening of transformants and purification of the affinity tagged protein.Journal of muscle research and cell motility · 1995Article
- Growth and developmental functions of a human immunodeficiency virus Tat-binding protein/26S protease subunit homolog from Dictyostelium discoideum.Molecular and cellular biology · 1995Article
- Genetic and physiologic modulation of the prestarvation response in Dictyostelium discoideum.Molecular biology of the cell · 1995Article
- Identification and functional analysis of a developmentally regulated extracellular signal-regulated kinase gene in Dictyostelium discoideum.Molecular and cellular biology · 1994Article
- Use of a transactive regulatory mutant of Dictyostelium discoideum in a eucaryotic expression system.Nucleic acids research · 1993Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Dictyostelium discoidin genes are induced in bacteria-grown cells shortly before the onset of development but are also highly expressed during growth in axenic medium. We here show that axenically growing cells strongly respond to the extracellular signal folate by suppressing discoidin synthesis while cell growth and development is not substantially affected. Repression occurs via two previously identified promoter elements, the dIE and the dAXE. Removal of the signal molecules or setting cells up for development results in rapid reactivation of the promoter. Based on this observation, we constructed the transformation vector pVEII and describe a convenient method which allows for controlled expression of a gene of interest in growing cells and also for external modulation in early development. Deletion constructs of the discoidin promoter can be used in addition to vary transcriptional activity over about one order of magnitude.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.