ArticleAmerican journal of human genetics2004
Genomewide scan in families with schizophrenia from the founder population of Afrikaners reveals evidence for linkage and uniparental disomy on chromosome 1.
Article in American journal of human genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Meta-analysis of 32 genome-wide linkage studies of schizophrenia.Molecular psychiatry · 2009Pooled it
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- A significant risk locus on 19q13 for bipolar disorder identified using a combined genome-wide linkage and copy number variation analysis.BioData mining · 2015Article
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- Fine mapping on chromosome 13q32-34 and brain expression analysis implicates MYO16 in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Exome sequencing supports a de novo mutational paradigm for schizophrenia.Nature genetics · 2011Article
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- G72 influences longitudinal change in frontal lobe volume in schizophrenia.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- Elucidating the genetic architecture of familial schizophrenia using rare copy number variant and linkage scans.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Chromosome 13q13-q14 locus overlaps mood and psychotic disorders: the relevance for redefining phenotype.European journal of human genetics : EJHG · 2009Article
- Genome-wide study of families with absolute pitch reveals linkage to 8q24.21 and locus heterogeneity.American journal of human genetics · 2009Article
- Genome-wide linkage scan for contraction velocity characteristics of knee musculature in the Leuven Genes for Muscular Strength Study.Physiological genomics · 2008Article
- Genetic variation in the DAOA gene complex: impact on susceptibility for schizophrenia and on cognitive performance.Schizophrenia research · 2008Article
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
We report on our initial genetic linkage studies of schizophrenia in the genetically isolated population of the Afrikaners from South Africa. A 10-cM genomewide scan was performed on 143 small families, 34 of which were informative for linkage. Using both nonparametric and parametric linkage analyses, we obtained evidence for a small number of disease loci on chromosomes 1, 9, and 13. These results suggest that few genes of substantial effect exist for schizophrenia in the Afrikaner population, consistent with our previous genealogical tracing studies. The locus on chromosome 1 reached genomewide significance levels (nonparametric LOD score of 3.30 at marker D1S1612, corresponding to an empirical P value of.012) and represents a novel susceptibility locus for schizophrenia. In addition to providing evidence for linkage for chromosome 1, we also identified a proband with a uniparental disomy (UPD) of the entire chromosome 1. This is the first time a UPD has been described in a patient with schizophrenia, lending further support to involvement of chromosome 1 in schizophrenia susceptibility in the Afrikaners.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.