ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Action potential timing determines dendritic calcium during striatal up-states.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Enhancement of calcium responses by KJournal of biosciences · 2026Article
- An ultra low frequency spike timing dependent plasticity based approach for reducing alcohol drinking.Scientific reports · 2024Article
- Article
- Differential Excitability of PV and SST Neurons Results in Distinct Functional Roles in Inhibition Stabilization of Up States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Cooperative synaptic and intrinsic plasticity in a disynaptic limbic circuit drive stress-induced anhedonia and passive coping in mice.Molecular psychiatry · 2021Article
- TrkB-dependent disinhibition of the nucleus accumbens is enhanced by ethanol.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Reinforcement determines the timing dependence of corticostriatal synaptic plasticity in vivo.Nature communications · 2017Article
- Calcium dynamics predict direction of synaptic plasticity in striatal spiny projection neurons.The European journal of neuroscience · 2017Article
- A Low-Correlation Resting State of the Striatum during Cortical Avalanches and Its Role in Movement Suppression.PLoS biology · 2016Article
- Dynamic modulation of spike timing-dependent calcium influx during corticostriatal upstates.Journal of neurophysiology · 2013Article
- GABAergic inputs from direct and indirect striatal projection neurons onto cholinergic interneurons in the primate putamen.The Journal of comparative neurology · 2013Article
- The effects of NMDA subunit composition on calcium influx and spike timing-dependent plasticity in striatal medium spiny neurons.PLoS computational biology · 2012Article
- Dopaminergic modulation of striatal neurons, circuits, and assemblies.Neuroscience · 2011Review
- A Ca(2+) threshold for induction of spike-timing-dependent depression in the mouse striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Modulation of striatal projection systems by dopamine.Annual review of neuroscience · 2011Review
- Facilitation of corticostriatal plasticity by the amygdala requires Ca2+-induced Ca2+ release in the ventral striatum.Journal of neurophysiology · 2010Article
- Cortico-striatal spike-timing dependent plasticity after activation of subcortical pathways.Frontiers in synaptic neuroscience · 2010Article
- Differences in biophysical properties of nucleus accumbens medium spiny neurons emerging from inactivation of inward rectifying potassium currents.Journal of computational neuroscience · 2009Article
- Gap junctions between striatal fast-spiking interneurons regulate spiking activity and synchronization as a function of cortical activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Feedforward and feedback inhibition in neostriatal GABAergic spiny neurons.Brain research reviews · 2008Article
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2 authors.
Funding
Abstract
Up-states represent a key feature of synaptic integration in cortex and striatum that involves activation of many synaptic inputs. In the striatum, the sparse firing and tight control of action potential timing is in contrast to the large intracellular membrane potential depolarizations observed during the up-state. One hallmark of striatal spiny projection neurons is the delay to action potential generation in both up-states and suprathreshold depolarization by somatic current injection. By studying somatic and dendritic intracellular calcium ([Ca2+]i) transients during spontaneous up-states in cortex-striatum-substantia nigra organotypic cultures, we show that the delay between up-state onset and action potential generation determines dendritic peak [Ca2+]i. Peak [Ca2+]i from single action potentials reached maximum values when action potentials were close to up-state onset and sharply decayed to near subthreshold up-state [Ca2+] levels as a function of time (tau = 47 +/- 26 msec for tertiary dendrite). Similarly, a precisely timed action potential elicited during subthreshold up-states through somatic current injection established that the delay between up-state onset and action potential generation is the critical variable that controls peak [Ca2+]i. Blocking NMDA channels internally with high intracellular Mg2+ ([Mg2+]i) (10 mm) abolished the dependency of peak [Ca2+]i on action potential timing during spontaneous up-states. Finally, high [Mg2+]i specifically blocked [Ca2+]i transients that resulted from local NMDA application in conjunction with backpropagating action potentials. We conclude that precisely timed, single action potentials during striatal up-states control peak dendritic calcium levels. We suggest that this mechanism might play an important role in synaptic plasticity of the corticostriatal pathway.
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